Unit 1: Peripheral Nerve Disorders and NMJ Pharmacology Flashcards Preview

Neuro > Unit 1: Peripheral Nerve Disorders and NMJ Pharmacology > Flashcards

Flashcards in Unit 1: Peripheral Nerve Disorders and NMJ Pharmacology Deck (26):
1

L1: Name a Clostridium toxin that causes flaccid paralysis

botulinum toxin

2

L1: Type of channel opened during fast excitation

Non-selective cation (NSC)

3

L1: Type of channel opened during fast inhibition

Chloride

4

L1: What pathologic process? Calf pseudohypertrophy, Gower's maneuver

Duchenne Dystrophy

5

L1: What pathologic process? Most common cause of neuropathy in the western world

Diabetic Neuropathy

6

L1: What pathologic process? Serum antibodies to the ACh receptor on muscle cells

Myasthenia Gravis

7

L2: Mechanism of Action of Black Widow Spider Venom

Form pore in presynaptic membrane to increase ACh release at the NMJ

8

L2: Mechanism of action of botulinum toxin

Cleave synaptobrevin and inhibit release of ACh at the NMJ

9

L2: Mechanism of action of curare

Blocks ACh receptors on muscle fibers

10

L2: Mechanism of action of tetanus toxin

Cleave synaptobrevin and inhibit release of inhibitory neurotransmitters in the CNS

11

L2: Name a drug that can be used to regenerate AChE following exposure to organophosphates that act as AChEIs

Pralidoxime

12

L2: Name a NMJ depolarizing antagonist

Succinylcholine

13

L2: Site of action for botulinum toxin

NMJ synapses

14

L2: Site of action for tetanus toxin

CNS

15

L2: What pathologic process? ______ disorder with mutations in dystrophin

X-linked; Duchenne/Becker Dystrophy

16

L2: What pathologic process? Antibody to voltage-gated calcium channels on the motor neuron

Myasthenic Syndrome

17

L2: What pathologic process? Distal weakness and sensory loss due to demyelination

Charcot-Marie-Tooth

18

L2: What pathologic process? Foot drop gait, burning dysesthesias in feet spreading up the legs

Diabetic Neuropathy

19

L2: What pathologic process? Initially presents as foot drop, hand deformity, fasciculations, and asymmetric limb weakness

Amyotrophic Lateral Sclerosis

20

L2: What pathologic process? Nerve tissue appears fibrotic and degenerative

Duchenne Dystrophy

21

L2: What pathologic process? Progressive kyphoscoliosis and contractures

Duchenne Dystrophy

22

L2: What pathologic process? Protuberant abdomen from lumbar lordosis, clumsy/waddling gait

Duchenne Dystrophy

23

L2: What pathologic process? Results from a defect in PMP22

Charcot-Marie-Tooth 1A

24

L2: What pathologic process? Sclerosis and demyelination of lateral corticospinal tract

Amyotrophic Lateral Sclerosis

25

L2: What pathologic process? Vast majority of cases are sporadic; death average of 3-4 years after diagnosis

Amyotrophic Lateral Sclerosis

26

L3: Name 3 NMJ nondepolarizing antagonists.

atracurium, rocuronium, curare