Unit 4: Alcohol Flashcards Preview

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Flashcards in Unit 4: Alcohol Deck (21):
1

L1: ____% of alcohol metabolism occurs in the liver.

90-98

2

L1: 90% of Asian have increased ______ activity and decreased _______ activity, leading to accumulation of acetaldehyde.

Acohol dehydrogenase; aldehyde dehydrogenase

3

L1: Accumulation of NADH leads to ____-glycemia

Hypoglycemia

4

L1: Accumulation of NADH results in ____ uric acid excretion, causing _______.

decreased; gout attacks

5

L1: Accumulation of NADH results in ______ blood lactate, causing _____-osis

increased; acidosis

6

L1: Metabolic Pathway: ethanol > _____ (catalyzed by _______) > ________ (catalyzed by _______)

acetaldehyde; alcohol dehydrogenase; acetic acid; aldehyde dehydrogenase

7

L1: The mechanism of action of alcohol intoxication involves _____ GABA transmission and ______ glutamate transmission

increased; decreased

8

L1: Which BAC level? Emesis, stupor, respiratory depression, blackouts

0.20-0.30

9

L1: Which BAC level? Impaired reaction time, impaired judgment, impaired driving ability, ataxia

0.05-0.08

10

L1: Which BAC level? Loss of inhibition, excitement, incoordination, impaired judgment, impaired speech

0-0.05

11

L1: Which BAC level? Staggering gait, inability to operate a motor vehicle

0.08-0.20

12

L1: Which BAC level? Unconsciousness, severe respiratory and cardiovascular depression, death

>0.30

13

L2: ______ inhibits aldehyde dehydrogenase to cause accumulation of acetaldehyde and its accompanying side effects

Disulfiram

14

L2: ______ is an opioid antagonist that deceases alcohol craving, consumption, and relapse

Naltrexone

15

L2: Accumulation of NADH results in _____ Acetyl-CoA, causing _____ fatty acid synthesis and ______ fat breakdown

increased; increased; decreased

16

L2: Accumulation of NADH results in _____ Magnesium excretion, causing ______.

increased; convulsions

17

L2: Alcohol is a vaso_____, conferring increased risk of _____thermia

dilator; hypothermia

18

L2: Disulfiram inhibits ________.

aldehyde dehydrogenase

19

L2: NMDA receptor drugs, such as ______, may produce some reduction in alcohol craving

Acamprosate

20

L2: Which agents may be used to prevent hyperexcitability in Alcohol Withdrawal Syndrome

BZDs, clonidine

21

L2: While BAC is rising, alcohol decreases _____ secretion in the kidneys

ADH