Flashcards in Unit 4: Alcohol Deck (21):
L1: ____% of alcohol metabolism occurs in the liver.
L1: 90% of Asian have increased ______ activity and decreased _______ activity, leading to accumulation of acetaldehyde.
Acohol dehydrogenase; aldehyde dehydrogenase
L1: Accumulation of NADH leads to ____-glycemia
L1: Accumulation of NADH results in ____ uric acid excretion, causing _______.
decreased; gout attacks
L1: Accumulation of NADH results in ______ blood lactate, causing _____-osis
L1: Metabolic Pathway: ethanol > _____ (catalyzed by _______) > ________ (catalyzed by _______)
acetaldehyde; alcohol dehydrogenase; acetic acid; aldehyde dehydrogenase
L1: The mechanism of action of alcohol intoxication involves _____ GABA transmission and ______ glutamate transmission
L1: Which BAC level? Emesis, stupor, respiratory depression, blackouts
L1: Which BAC level? Impaired reaction time, impaired judgment, impaired driving ability, ataxia
L1: Which BAC level? Loss of inhibition, excitement, incoordination, impaired judgment, impaired speech
L1: Which BAC level? Staggering gait, inability to operate a motor vehicle
L1: Which BAC level? Unconsciousness, severe respiratory and cardiovascular depression, death
L2: ______ inhibits aldehyde dehydrogenase to cause accumulation of acetaldehyde and its accompanying side effects
L2: ______ is an opioid antagonist that deceases alcohol craving, consumption, and relapse
L2: Accumulation of NADH results in _____ Acetyl-CoA, causing _____ fatty acid synthesis and ______ fat breakdown
increased; increased; decreased
L2: Accumulation of NADH results in _____ Magnesium excretion, causing ______.
L2: Alcohol is a vaso_____, conferring increased risk of _____thermia
L2: Disulfiram inhibits ________.
L2: NMDA receptor drugs, such as ______, may produce some reduction in alcohol craving
L2: Which agents may be used to prevent hyperexcitability in Alcohol Withdrawal Syndrome