Unit 4 Dermatology Images Flashcards Preview

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Flashcards in Unit 4 Dermatology Images Deck (52):
1

  • absence of melanocytes
  • causes depigmentation

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Vitiligo

2

  • associated with defects in collagen support structure of dermis

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Ehlers-Danlos Syndrome

3

  • location: flexor surfaces in adults
  • etiology: filaggrin mutation
  • associated with asthma and allergic rhinitis
  • staph aureus is suggested to exacerbate this disorder
  • in children, is on cheecks and extensor surfaces
  • eczema is type of atopic dermatitis

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Atopic Dermatitis

4

  • type of atopic dermatitis

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Eczema

5

  • etiology: common irritants
  • caused by perfume, soap, etc

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Irritant Contact Dermatitis

6

  • etiology: common allergens
  • delayed type hypersensitiviey reaction (type 4)
  • diagnosis confirmed with patch testing
  • skin biopsy would reveal spongiotic dermatitis
  • caused by poison ivy

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Allergic Contact Dermatitis

7

  • location: lower legs
  • etiology: lower extremity edema

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Stasis Dermatitis

8

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Lichen Simplex Chronicus

9

  • same as nummular eczema
  • round, annular, scaly plaques
  • due to dry skin
  • overuse of soap can make this worse

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Numular Dermatitis

10

  • location: scalp
  • etiology: malassezia furfur
  • also known as cradle cap
  • infection of sebaceous glands

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Seborrheic Dermatitis

11

  • location: extensor surfaces
  • may include arthritis
  • may be associated with increased cardiovascular risk

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Chronic Plaque Psoriasis

12

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Guttate Psoriasis

  • associated with strep

13

  • skin cancer
  • most common
  • pearly
  • common on nose
  • common PATCH1 mutation: most BCC have loss of PATCH1 that normally block SMOOTHENED gene
  • tx: mohs surgery, vismoedgib (blocks smoothend gene)

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Basal Cell

14

  • second most common skin cancer
  • occurs more common in immunosupporessed pts
  • keratoacanthoma is a type of this cancer
    • center crater
    • develop rapidly
  • on sunexposed skin, HPV, thermal injury
  • actinic keratosis is premalignant skin lesion

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Squamous Cell

15

  • skin cancer
  • common mutation: BRAF
  • tx: vemurafinib
  • breslow thickness: measurement of depth of tumor
  • clark level: layers of skin affected

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Melanoma

16

  • often associated with immunodeficiency

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Kaposi Sarcome

17

  • can be treated with beta blockers
  • most common benign soft tissue tumor of infants
  • GLUT1 positive

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Infantile Hemangioma

18

  • most common benign vascular tumor in adults

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Cherry Angioma

19

  • associated with high levels of GLUT-1 expression (a placenta associated marker)
  • also called strawberry hemangioma
  • often develops rapidly in first 3 months of life
  • involution (decrease) common into adulthood (50% by 5, 70% by 7, 90% by 9)

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Infantile Hemangioma

20

  • associated with glaucoma and seizures
  • assocaited with sturge weber in infants with port wine stain in trigemminal nerve

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Port Wine Stain

21

  • linear plaque on the face or scalp
  • yellow-orange
  • associated with allopecia
  • assocated with mutations in HRAS and KRAS

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Nevus Sebaceus

22

  • most commonly on face>trunk>extremity
  • beign tumor of oil gland

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Sebaceus Hyperplasia

23

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Acrochordon

24

  • benign tumor of adipose tissue
  • often soft, movable, painless

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Lipoma

25

  • from fibroblast
  • firm papule
  • most common on legs
  • dimple sign is characteristic (Fitzpatrick sign)

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Dermatofibroma

26

  • scar gowth above and beyond original border
  • composed of type 3 or type 1 collagen

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Keloid Scar

27

  • sudden appearance associated with adenocarcinoma of the stomach
  • barnicles of life
  • appear dark in people with dark complexion- Morgan Freeman

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Seborrheic Karatosis

28

  • head and neck most common
  • similar in color to shade of skin

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Intradermal Nevus

29

  • flat macules
  • palms and soles most common

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Junctional Nevus

30

  • trunk and proximal extremities
  • color brown to black

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Compound Nevus

31

  • more common in asians and causcasians

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Blue Nevus

32

  • low risk of progressing to malignant melanoma

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Congenital Nevi

33

  • usually apparent by 20 years

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Dysplastic Nevus

34

  • biggest risk factor for melanoma
  • familial atypical moles and melanoma
  • criteria:
    • The occurrence of malignant melanoma in 1 or more first- or second-degree relatives

    • The presence of numerous (often >50) melanocytic nevi, some of which are clinically atypical

    • Many of the associated nevi showing certain histologic features

  •  CDK2NA mapped to 9p21 

  • CDK4 mapped to 12q14  

  • CMM1 mapped to 1p

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FAMMM Syndrome

35

  • six or more cafe au lait spots
  • two or more neurofibromas
  • axillary or inguinal freckling (Crowe's sign)
  • first degree relative with disorder
  • optic glioma (iris freckles)
  • autosomal dominant
  • Defect in neurofibromin gene, a tumor suppressor, on chromosome 17 for NF-1

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Neurofibromatosis

36

  • multiple lesions associated with neurofibromatosis

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Cafe au Lait Patch

37

  • melassezia furfur is causative agent
  • diagnos with KOH

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Tinea Versicolor

38

  • acquired disease involving antibodies to cell-to-cell adhesion molecules in the stratum spinosum (keratinocytes)
  • attacks desmosomes

Permphigus Vulgaris

39

  • vitamin cross links tropocollagen together
  • this disease is characterized by lack of vitamin C
  • SS: keratotic plugging of hairs, corkscrew hairs, hemorrhagic gingivitis

Scurvy

40

  • type 2 antibody mediated
  • detachment between dermis and epidermis- hemidesomsomes

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Bullous Pemphigoid

41

42

  • do not debride
  • tx with steroids and immunosuppression

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Pyoderma Gangrenosum

43

  • associated with hepatitis

Lichen Planus

44

  • with internal malignancies, pts tend to have weight loss- most common is stomach cancer
  • thickening of the skin
  • common causes: obesity, diabetes

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Acanthosis Nigricans

45

  • filagrin mutation

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Icthyosis Vulgaris

46

  • honey colored
  • associated with bacteria like strep and staph
  • can be bullus (staph) or non-bullus (strep/staph)

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Impetigo

47

  • begins 7-14 days after taking new medication
  • located over trunk and extremities

Drug Eruption

48

  • inital presentation is chancre
  • secondary skin lesions form 4-10 weeks after onset of chancre
  • sometimes presents with lymphadenopathy
  • moth-eaten alopecia

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Syphilis

49

  • can also have black dot appearance
  • casued by fungus
  • test is KOH, dermatophyte test medium (changes colors)
  • other types:
    • tinia faciei- face
    • tinia barbae- beard area
    • tinia corpus- body
    • tinia pedis- feet
    • tinia manum- one hand two feet syndrome

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Tinia Capitis

50

fungus under nails

Onychomycosis

51

  • infestation
  • burrows and genital nodules
  • use mineral oil wet prep for diagnosis

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Scabies

52

 

  • fungus

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Oral Candidiasis (Thrush)