Unit 4: Psychosis and Anti-Psychotic Agents Flashcards Preview

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Flashcards in Unit 4: Psychosis and Anti-Psychotic Agents Deck (38):
1

L1: ______ antipsychotic agents have a high D2/5HT2A ratio.

Typical

2

L1: ______ antipsychotic agents have a low D2/5HT2A ratio.

Atypical

3

L1: ______ antipsychotic agents have good efficacy against negative symptoms.

Atypical

4

L1: ______ antipsychotic agents have good efficacy against postive symptoms primarily.

Typical

5

L1: In typical antipsychotic agents, ____ potency agents have greater antihistamine side effects

low

6

L1: In typical antipsychotic agents, ____ potency agents have greater risk of dry mouth and sedation.

low

7

L1: In typical antipsychotic agents, ____ potency agents have greater risk of extrapyramidal side effects

high

8

L1: In typical antipsychotic agents, ____ potency agents have greater risk of hypotension.

low

9

L1: In typical antipsychotic agents, ____ potency agents have less alpha-blockade

high

10

L1: In typical antipsychotic agents, ____ potency agents have less anti-muscarninc toxicity

high

11

L1: In typical antipsychotic agents, ____ potency agents have less extra-pyramidal toxicity.

low

12

L1: Name a typical high-potency antipsychotic agent.

Haloperidol

13

L1: Name an antipsychotic agent with high risk of tardive dyskinesia.

Haloperidol

14

L1: Name an antipsychotic agent with pseudoparkinsonism and akathisia as notable side effects.

Haloperidol

15

L1: Name an antipsychotic agent with risk of agranulocytosis, leading to limited use.

Clozapine

16

L1: Name the two most common positive symptoms in psychosis.

Delusions, Hallucinations

17

L2: ______ activation of NMDA receptors on GABAergic interneurons in the prefrontal cortex results in _____ symptoms.

Decreased; positive and negative

18

L2: Acitvation of 5HT2A receptors on dopamine neurons in the prefrontal cortex _______ dopamine release, causing ____ symptoms.

decreases; negative

19

L2: Activation of _______ receptors can increase dopamine release in the mesolimbic pathway.

5HT2A

20

L2: First generation antipsychotic agents antagonize the _______.

D2 dopaminergic receptor

21

L2: Hypofunction in NMDA-Glu > _____ GABA > ______ Glu > _____ VTA GABA interneurons > ______ mesocortical dopamine neurons > _____ symptoms

decreased; increased; increased; decreased; negative

22

L2: Hypofunction in NMDA-Glu > _____ GABA > ______ Glu > _____mesolimbic dopamine neurons > _____ symptoms

decreased; increased; increased; positive

23

L2: Hypofunction in NMDA-Glu neurons causes ______ GABA inhibition

decreased

24

L2: Hypofunction in NMDA-Glu neurons leads to _____ activity of cortical glutamate neurons.

increased

25

L2: In schizophrenic brains, the ______ which modulates executive function, has been shown to have widened sulci and volume reduction

Dorsolateral Prefrontal Cortex (DLPFC)

26

L2: In schizophrenic brains, there are _____ dendritic spines and presynaptic axonal inputs.

decreased

27

L2: In schizophrenic brains, there are reduced _______ proteins and neuronal fucntion in the dorsolateral prefrontal cortex.

GABAergic interneuron

28

L2: In the dopamine theory of schizophrenia, there is ____ activity of the mesocortical dopamine neurons, resulting in ______ symptoms.

decreased; negative

29

L2: In the dopamine theory of schizophrenia, there is _____ activity of the mesolimbic dopamine neurons, resulting in _____ symptoms.

increased; positive

30

L2: In the glutamate theory of schizophrenia, there is _____ activity, resulting in schizophrenic-like symptoms.

decreased

31

L2: Name a typical low-potency antipsychotic agent.

Chlorpromazine

32

L2: Name an antipsychotic agent with efficacy in most patients refractory to other drugs.

Clozapine

33

L2: Under normal physiologic conditions, the tuberoinfundibular pathway involves hypothalamic neurons release of dopanine to inhibit _______.

Prolactin release

34

L2: Which class of antipsychotic agents is associated with parkinsonism and tardive dyskinesia?

Typical Antipsychotic Agents

35

L2: Which class of antipsychotic agents is associated with weight gain, hypercholesteroleia, and diabetes mellitus?

Atypical Antipsychotic Agents

36

L3: In schizophrenic brains, there is _____ size and packing density of _______ in the _____ cortex

decreased; pyramidal neurons; prefrontal

37

L3: Second generation antipsychotic agents (atypical antipsychotics) antagonize the ________.

D2 dopaminergic and 5HT2 serotoninergic receptors

38

L4: Name 5 atypical antipsychotic agents.

Risperidone, olanzapine, clozapine, aripiprazole, Quetiapine