Unit 5: Part 1 acquired immunity on exam 2 Flashcards Preview

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Flashcards in Unit 5: Part 1 acquired immunity on exam 2 Deck (16):
1

define attenuated live vaccines

weakened, non pathogenic live org

2

eg of attenuated live vaccines

Sabin or oral polio vaccine, varicella, measles, mumps, and rubella (MMR)

3

define killed/inactivated vaccines

contain heat or chemically killed microbes

4

process of attenuated vaccine

virus repeatedly grown in suboptimal envirmt. small # might mutate to survive. select imunogenic but avirulent (non pathogenic strain) for testing. choose best for vaccine

5

define toxoid vaccine

compose of exotoxins that are modified chemically or physically to remove toxigenicity but retain immunogenicity

6

eg of toxoid vaccine

diphtheria and tetanus

7

define subunit or acellular vaccine

composed of purified microbial components (can be conjugated to carrier) do not contain whole virus/cells

8

how are subunit/ acellular vaccines produced

by recombinant DNA technology

9

how is acellular Pertussis (aP) acellular vaccine produced

contains 2+ protective antigens of Bodetella pertussis

10

describe pneumococcal vaccine

capsular polysaccharides of 23 serotypes (strains) of S. pneumoniae. 23 valent vaccine

11

describe HBV vaccine

surface antigen on the envelope of HBV is the protective antigen

12

eg of killed/inactivated vaccine

injected Salk or inactivated poli vacine

13

how is HBV vaccine synthesized

expression vector (yeast Saccharomyces cervisiae) in which plasmid contain gene for HBAg was inserted. eg of rDNA vaccine

14

what is IG/antisera

contain pre-formed Ab against infectious agents and toxins

15

when to use IG/antisera

vaccine not recommended (ie live for pregnant), vaccine not available eg botulism, immediate protection (only short term) (eg animal bites), w/other vaccines (HBV-IG and HBV vaccine for babies)

16

describe Hemophilus influenzae tybe b (Hib) acellular vaccine

purified bacterial polysaccharide conjugated to protein