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Flashcards in Urinary Drugs Deck (17)
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1

Anticholinergic Drugs

Darifenacin, oxybutynin, Solifenacin, Trospium

2

Which anticholinergic is M3 selective

Darifenacin

3

Darifenacin, oxybutynin, solifenacin Tox

Peripheral: dry mouth, mydriasis, constipation, urinary retention, tachycardia; Central: sedation, confusion, hallucinations, slowed cognitive fxn, sleep disruption

4

Trospium Tox

Peripheral: dry mouth, mydriasis, constipation, urinary retention, tachycardia; LEAST likely to prod central effects b/c Quaternary

5

Darifenacin PK

2D6 + 3A4; 13-19 hr half-life; poor oral bioavailability

6

oxybutynin PK

3A4; 2 hr half-life; poor oral bioavailability; give extended release

7

Solifenacin PK

3A4; 45-68 hr half-life; 90% bioavailability

8

Trospium PK

No CYP metabolism; 12-20 hr half-life; poor oral bioavailability (take on empty stomach)

9

Mirabegron MOA

Beta-3 Agonist; increases bladder capacity by relaxing detrussor smooth muscle

10

Mirabegron Tox

Increases BP- monitoring recommended esp in HTN pts; tachycardia

11

MIrabegron PK

3A4 >> 2D6; also butylcholinesterase, UGT, & alcohol dehydrogenase; 50 hr half-life; oral bioavailability dec by food

12

Neostigmine MOA

Inhibits Ach-Esterase; augments action of Ach at both muscarinic & nicotinic receptors

13

Neostigmine Tox

AV Block, Bradyarrhythmias, Cardiac arrest, Cardiac dysrhythmia, Hypotension, Syncope, Tachycardia

14

Neostigmine PK

Inactivated by cholinesterases & hepatic microsomal enzymes; half-life < 1 hr; poor oral bioavailability

15

Which drug is used for treatment of urinary retention

Neostigmine

16

AE of anticholinergics

urinary retention, CV (palpitations, tachycardia, prolonged QTc interval), GI (constipation)

17

CI of anticholinergics

angle closure or narrow-angle glaucoma
urinary and gastric obstruction
need for mental alertness
Alzheimer's type dementia