Flashcards in Uworld Exam 12 Deck (63):
What does Ubiquitin do? What is the result of a mutation in ubiquitin?
Ubiquitin=labels proteins for degradation by proteasomes
Mutation=>misfolded proteins accumulating
opioid withdrawal, what are its symptoms?
pupillary dilatation, rhinorrhea, sneeziing, nasal stuffiness, diarrhea
Tx of opioid withdrawal?
Give some opioids
COX-1 helps maintain what?
gastric mucosa by mucous
Main Reason to use a COX-2 Inhibitor (celecoxib)?
Prevent gastric ulcerations and reduced risk of bleeding
kinesin and dyenin are associated with what functional unit?
Topoisomerase I and II do what?
relieve unwinding tension
RNA primase does what? What is its purpose?
provides a primer to free up a free 3'OH group
What does DNA polymerase I do?
removes RNA primer and exonuclease
What does DNA polymerase III do?
Taking up of naked DNA by cell
Sudden Change in antigen by mixing two normal viruses
Defective viruses mixing and becoming virulent
Linear Mucosal Tear in alcoholics with hematemesis?
Mallory Weiss Tear
Transmural Mucosal Tear with esophageal air/fluid leakage NOT blood?
Mallory Weiss Tear leads to what Acid Base disturbance?
Phase 4 consists of spontaneous depolarizations that are due to what three things?
1. K+ channel closure
2. Na+ funny channel opening
3. L-type Ca2+ channels opening
Horseshoe kidney trapped by?
What traps SMA?
In Patients with myasthenia gravis, what other extramuscular abnormality exists?
abnormalities of the thymus (thymoma, thymic hyperplasia)
Patient who complains of weakness and heaviness in her eyelids at the end of the day or an activity?
What muscles are most susceptible in a patient with MG?
Where does Thymus originate from? What other organ is with it in this pouch?
Inferior parathyroid glands
Spherules containing endospores?
Who kills cells that don;t have MHC class I?
How do NK cells kill?
With Perforin and Granzymes to induce apoptosis
NK cells exhibit what CD?
CD 16 and 56
Are NK cells present in Athymic patients? Do they have memory?
NK cells are activated by what two cytokines?
What ions regulate electrical potential?
Na, K and Cl
In resting membrane, where are the main ions located in a cell? Extracellular or Intracellular?
Gram negative cocci in pairs suggests what organism?
Best drug for prophylaxis of neisseria?
Coagulopathies like increased PTT or PT are from what kind of bleeding?
deep tissue bleeding-joints, muscles
Platelet defects shows as what kind of bleeding?
mucocutaneous bleeding (epistaxis, petechiae)
Prolonged PT? what pathway is wrong?
Prolonged PTT? what pathway is wrong?
Absolute Risk Reduction formula?
Event rate in Control-Event Rate in treatment
ALA synthase requires what cofactor?
Passive Extension of the arm, there is initial resistance followed by a sudden release of tension as extension continued. What is this phenomenon called? Where do you see this symptom?
Internal capsule stroke will lead to what kind of symptoms?
Pure Motor: Contralateral arm, leg and lower face weakness
Lesion in caudate nucleus will lead to?
EPS symptoms like chorea and athetosis
QRS prolongation is due to what class of antiarrythmic drug?
With a stable set of incidence, how do you increase prevalence?
Increased quality of care
Tet Spells help increase? To improve what?
systemic vascular resistance, oxygenation
With all urea cycle disorders, what do you food do you need to restrict?
Muscle weakness and fatigue with a particular ion?
What 3 cytokines mediate inflammation?
IL-1, IL-6, and TNF alpha
LTB4, C5a, IL-8, 5-HETE are what kind of agents? These mediate the accumulation of?
anticoagulated RBCs fall at a rate of 35 mm per hour?
MOA: bind to ATP dependent K+channels
Somatostatin is produced by?
Exogenous Insulin vs insulinoma?
Serum Insulin both elevated
C-peptide decreased in Exogenous insulin
BUT NOT in Insulinoma
Holoproscencephaly is due to?
In chronic diabetics DM2 what do you see in their islet cells?
DM is related to what HLA?
Neurological deficit, marked pallor (anemia)?
B12 def=>megaloblastic anemia
CN 7 has what symptoms?
1. Facial Motor Output symptoms
2. Parasymp. innervation to lacrimal, submandibular, sublingual
3. 2/3 of taste of tongue
4. external auditory canal
Live Attenuated Virus?
Live! One night only! See small yellow
rotating chickens get vaccinated with Sabin
and MMR! It’s incredible
Smallpox, yellow fever, rotavirus, chickenpox (VZV), Sabin polio virus, MMR, Influenza (intranasal)
Propionyl Co-A Carboxylase
Acetyl Co-A Carboxylase