Uworld Exam 14 Flashcards Preview

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Flashcards in Uworld Exam 14 Deck (50):
1

Gag protein on HIV is? What does it encode for?

Gp 24
Capsule

2

Env protein on HIV is?

Gp 120, Gp41
Envelope=>to absorb the virion

3

Pol Protein on HIV is?

Reverse Transcriptase

4

CEA is for?

Tumor Recurrance

5

Suppressed with Dexamesthone?

Pituitary Adenoma

6

Not Suppressed with Dexamesthone?

Ecotopic ACTH production

7

Suppressed ACTH Levels?

Adrenal Adenoma/Exogenous Glucocorticoids

8

With Inhaled Corticoidsteroids, watchout for?

Oral Candidasis
Oral Rinse

9

Most Preventable cause of death?

Smoking

10

Ways to prevent mortality? What is #1 and #2

#1=stop smoking
#2=aspirin therapy

11

Infant with poor feeding, increased head circumference and enlarged ventricles on CT?

Hydrocephalus

12

Long term complication of Hydrocephalus?

Hypertonicity and hyperreflexia due to Upper Motor Neuron Lesion

13

consists of two immunoglobulin monomers, J chain and secretory component. What is the immunoglobulin?

IgA

14

Ureteral Constriction decreases?

GFR and FF

15

How do you check for Menopause?

FSH and estradiol levels NOT LH

16

Actin attaches to?

An Interesting Zoo
Must Have Mammals

Actin I-Band to the Z line
Myosin H-band to the M-line

17

Sun Exposure leads to? How do you fix it? When does this occur?

DNA damage via pyrimidine dimers
Endonuclease nicking of the damaged DNA strand
G-1 phase

18

Ataxia-Telangiectasia MOA? You bring it together via?

MOA: 2 ds DNA breakage
Repair: Non-homologous end joining

19

Base Excision Repair MOA?

MOA: Base specific glycoylase removes altered base and creates AP site
Occurs throughout the cycle

20

Mismatch Repair occurs in what disease? When does this occur?

HNPCC
G-2 phase

21

PAO2 equation?

150-PaCO2/0.8

22

Enoxaparin MOA

MOA: Binds to antithrombin to inhibit to factor Xa

23

Fondaparinux MOA

MOA: Xa Inhibitor

24

Unfractionated Heparin MOA

MOA: Binds to antithrombin to inhibit Factor Xa and Thrombin

25

Zona fasciulata secretes?

cortisol

26

Zona Reticulata secretes?

Androgen

27

3 SD equals?

99.7%

28

CN 9 innervates

Somatic: Stylopharygneus
Parasymp: Otic Ganglion=>parotid gland secretion
Sensation: tympanic membrane, eustachian tube, tonsillar region, upper pharynx (gag reflex afferent)
Others: carotid sinus and body

29

DOC for malaria? If resistant, next line of choice?

DOC: chloroquine
Next in line: Mefloquine

30

Difficulty walking with a history of diarrhea?

Guian Barre Syndrome with Camplyobacter (MC)

31

After infusion of nitroprusside, patient feels lethargic and confused, lactic acidosis and bright red venous blood, what happened?

CN toxicity

32

How do you treat CN Toxicity?

Sodium Nitrite=>makes it into methemoglobinemia

Sodium Thiosulfate=>Sulfur donating to change cyanate to thiocyanate

Hydroxycobalamin=>forms cyanocobalamin to be excreted

33

Increased erythrocyte mass, facial pleothra, splenomegaly?

Polycythemia Vera

34

Polycythemia vera has a mutated what pathway?

JAK2

35

JAK2 is what kind of receptor

Cytoplasmic tyrosine kinase

36

1st line for antiemetic therapy?

5-HT3 antagonist=>ondanstreon

37

Vancomycin MOA AE?

MOA: Blocks glycopeptide polymerization by binding tightly to D-ALA, D-ALA
AE: Redman syndrome, Nephrotoxicity

38

Daptomycin MOA AE?

MOA: depolarization of cellular membrane
AE: muscle pain, inactivated by pulmonary surfactant

39

Linezolid MOA AE?

MOA: Inhibits bacterial protein syntehsis by binding to the 50s subunit
AE: Thrombocytopenia, Optic Neuritis, Serotonin Syndrome

40

MCC of aseptic meningitis

Enterovirus

41

Amyloid associated with Alzheimer's is?

AB amyloid

42

AB amyloid is made by what gene?

APP

43

AB amyloid can lead to?

Amyloid angiopathy

44

Isonazid Resistance?

Non expression of catalase peroxidase

45

In primary renal insuffiency what will the lab values be for Na, K, Cl and Bicarb

Na=down
K=up
Cl=up
Bicarb=down

46

EHEC produces a toxin that is most similar to?

Shigella

47

Excessive worrying for over?

6 months

48

MEN2A

Medullary Thyroid Cancer, Pheochromoctyoma and parathyroid

49

What gene is affected in MEN 2A and 2B?

RET

50

Medullary Thyroid Cancer Histology?

polygonal cells with extracellular amyloid deposits