Flashcards in Uworld Exam 14 Deck (50):
Gag protein on HIV is? What does it encode for?
Env protein on HIV is?
Gp 120, Gp41
Envelope=>to absorb the virion
Pol Protein on HIV is?
CEA is for?
Suppressed with Dexamesthone?
Not Suppressed with Dexamesthone?
Ecotopic ACTH production
Suppressed ACTH Levels?
Adrenal Adenoma/Exogenous Glucocorticoids
With Inhaled Corticoidsteroids, watchout for?
Most Preventable cause of death?
Ways to prevent mortality? What is #1 and #2
Infant with poor feeding, increased head circumference and enlarged ventricles on CT?
Long term complication of Hydrocephalus?
Hypertonicity and hyperreflexia due to Upper Motor Neuron Lesion
consists of two immunoglobulin monomers, J chain and secretory component. What is the immunoglobulin?
Ureteral Constriction decreases?
GFR and FF
How do you check for Menopause?
FSH and estradiol levels NOT LH
Actin attaches to?
An Interesting Zoo
Must Have Mammals
Actin I-Band to the Z line
Myosin H-band to the M-line
Sun Exposure leads to? How do you fix it? When does this occur?
DNA damage via pyrimidine dimers
Endonuclease nicking of the damaged DNA strand
Ataxia-Telangiectasia MOA? You bring it together via?
MOA: 2 ds DNA breakage
Repair: Non-homologous end joining
Base Excision Repair MOA?
MOA: Base specific glycoylase removes altered base and creates AP site
Occurs throughout the cycle
Mismatch Repair occurs in what disease? When does this occur?
MOA: Binds to antithrombin to inhibit to factor Xa
MOA: Xa Inhibitor
Unfractionated Heparin MOA
MOA: Binds to antithrombin to inhibit Factor Xa and Thrombin
Zona fasciulata secretes?
Zona Reticulata secretes?
3 SD equals?
CN 9 innervates
Parasymp: Otic Ganglion=>parotid gland secretion
Sensation: tympanic membrane, eustachian tube, tonsillar region, upper pharynx (gag reflex afferent)
Others: carotid sinus and body
DOC for malaria? If resistant, next line of choice?
Next in line: Mefloquine
Difficulty walking with a history of diarrhea?
Guian Barre Syndrome with Camplyobacter (MC)
After infusion of nitroprusside, patient feels lethargic and confused, lactic acidosis and bright red venous blood, what happened?
How do you treat CN Toxicity?
Sodium Nitrite=>makes it into methemoglobinemia
Sodium Thiosulfate=>Sulfur donating to change cyanate to thiocyanate
Hydroxycobalamin=>forms cyanocobalamin to be excreted
Increased erythrocyte mass, facial pleothra, splenomegaly?
Polycythemia vera has a mutated what pathway?
JAK2 is what kind of receptor
Cytoplasmic tyrosine kinase
1st line for antiemetic therapy?
Vancomycin MOA AE?
MOA: Blocks glycopeptide polymerization by binding tightly to D-ALA, D-ALA
AE: Redman syndrome, Nephrotoxicity
Daptomycin MOA AE?
MOA: depolarization of cellular membrane
AE: muscle pain, inactivated by pulmonary surfactant
Linezolid MOA AE?
MOA: Inhibits bacterial protein syntehsis by binding to the 50s subunit
AE: Thrombocytopenia, Optic Neuritis, Serotonin Syndrome
MCC of aseptic meningitis
Amyloid associated with Alzheimer's is?
AB amyloid is made by what gene?
AB amyloid can lead to?
Non expression of catalase peroxidase
In primary renal insuffiency what will the lab values be for Na, K, Cl and Bicarb
EHEC produces a toxin that is most similar to?
Excessive worrying for over?
Medullary Thyroid Cancer, Pheochromoctyoma and parathyroid
What gene is affected in MEN 2A and 2B?