Vasculitis Flashcards
(36 cards)
Which condition is cANCA positive and associated with anti-PR3?
GPA
How is Henoch Schonlein purpura treated?
This is self limiting, and will settle over weeks-months
GPA can be diagnosed if at least 2 of what 4 features are present?
Nasal/oral inflammation, abnormal chest radiograph, urinary sediment, granulomatous inflammation on biopsy
What are some common symptoms of GCA?
Headache, visual changes, jaw claudication, scalp tenderness
If someone has features of temporal arteritis, what investigation is indicated?
Temporal artery biopsy
What types of imaging may be useful for large vessel vasculitis?
MR angiogram or PET CT
What are some features which vary with disease activity in small vessel vasculitis?
ANCA, anti-PR3, anti-MPO and C3/4
MPA is positive for which type of ANCA?
pANCA
How is large vessel vasculitis treated?
Initially with 40-60mg prednisolone, then DMARDs e.g. methotrexate/azathioprine may be considered
Apart from the rash, what are some other potential features of Henoch Schonlein purpura?
Colicky abdominal pain, vomiting and joint pain/swelling
Who is Takayasu arteritis most commonly seen in?
Usually females aged < 50, often Asian origin
Which vessels are most commonly involved in Takayasu arteritis?
Aorta, femoral and subclavian arteries
What investigations should be used for diagnosis of ANCA vasculitis?
Routine bloods, antibody screen, urinalysis, CXR and biopsy of an affected area
If large vessel vasculitis is left untreated- what can this lead to?
Claudicant symptoms in the limbs, reduced pulses and bruits
ENT symptoms are common in GPA. What are some examples?
Nasal crusting, epistaxis, deafness, recurrent sinusitis
What are some neurological features of small vessel vasculitis?
Mononeuritis multiplex (causing symptoms e.g. foot/wrist drop) and a glove and stocking distribution peripheral neuropathy
What are some typical features of all kinds of small vessel vasculitis?
Purpuric rash, mononeuritis multiplex, glomerulonephritis, lung opacities
Who does Henoch Schonlein purpura usually occur in? What typically precedes its occurrance?
Usually occurs in children, with a history of a recent URTI (usually GAS)
EGPA presents similarly to GPA- what are some features that characterise EGPA?
Late onset asthma, rhinitis and a peripheral blood eosinophil count of > 10%
Kawasaki disease can cause vasculitis of various vessels, but which do we worry about most?
The coronary arteries
What is an important feature of an FBC seen in ANCA vasculitis?
Anaemia of chronic disease
What investigation should be done in everyone presenting with Henoch Schonlein purpura and why?
Urinalysis, as renal involvement occurs in 50% of cases
‘Saddle nose’ is a sign associated with which type of vasculitis?
GPA
Who is Kawasaki disease usually seen in?
Children aged < 5
