Vector-borne and zoonotic bacterial infections Flashcards Preview

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Flashcards in Vector-borne and zoonotic bacterial infections Deck (33):
1

Rickettsia species causes

Spotted fevers and typhus

2

Erlichia chaffeensis causes

Human monocytic ehrlichiosis

3

Anaplasma phagocytophilum causes

Anaplasmosis

4

Borrelia burgdorferi causes

Lyme disease

5

What does borrelia burdorferi look like?

Spirochete, hard to visualize with gram stain because it's so small.

6

Lyme disease rash called

Bulls eye or erythema migrans

7

Can lyme disease affect the heart?

Yes causes heart block.

8

What is the vector for B. burgdorferi?

Ixodes scapularis (blacklegged tick).

9

Where is B. burgdorferi common?

Northeast

10

Reservoir for burgdorferi?

White footed mice, which are bitten by Ixodes scapularis

11

Why are deer significant in lyme disease?

Because they keep adult ticks (that are carrying Borrelia burgdorferi) alive

12

What stage of ixode development is most significant for causing disease?

Nymph

13

Phases of lyme disease

Early localized: characterized by erythemia migrans and mild systemic symptoms (fever, chills).

Early disseminated: Meningitis, Bell's Palsy, heart block, rash.

Late disease: Arthritis on knees, chronic neurological problems

14

How to diagnose?

Clinical picture, IgG and IgM antibody tests.

15

How to treat lyme disease

Oral doxycycline (amoxicillin in children), or if it gets serious, cefriaxone.

16

Leptospirosis caused by

Leptospira species. Comes from raccoon urine that is picked up by dogs, can be transmitted to humans.

17

Diagnosis of leptospirosis?

Serology, look for serum antibodies

18

Treatment of leptospirosis

Penicillin

19

Symptoms of leptospirosis

Hematogenous spread causing fever and headache. Then full blown disease occurs causing meningitis, nephritis, hepatitis, rash.

20

Rickettsia Rickettsii causes

Rocky Mountain Spotted Fever

21

Rickettsia Rickettsii gram stain?

None.

22

Reservoir?

Hard ticks, also the vector

23

Why is it so important?

23% mortality

24

How is R. rickettsii pathogenic?

Obligate intracellular organism

25

Where does R. rickettsii occur?

Southeast

26

What are the symptoms of rocky mountain spotted fever?

Fever, headache, spotted rash.

27

How does R. rickettsii enter the cell?

At endothelial cell! Induces its own phagocytosis, releases phospholipase to escape from the phagosome and propels itself by using host cell actin.

28

Ehrlichiosis caused by?

Ehrlichia chaffeensis

29

What happens in ehrlichiosis?

Monocytes are invaded

30

What causes anaplasmosis?

Anaplasma phagocytophilium

31

What happens in anaplasmosis?

Granulocytes invaded.

32

Where do ehrlichiosis and anaplasmosis occur?

E: Southeast
A: Northeast

33

How to treat rickettsia, ehrlichiosis, and anaplasmosis?

Immediate doxycycline.