Venous Thrombosis Flashcards

1
Q

Is it platelets or fibrin than are the problem in arterial thrombosis?

A

Platelets

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2
Q

Are arterial thrombi venous or platelet rich?

A

Platelet

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3
Q

What are the tretament for arterial thrombus prevention?

A

Aspririn and other anti platelet drugs?

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4
Q

Are venous thrombus rich in platelets or fibrin?

A

Fibrin

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5
Q

Is it platelets or fibrin than are the problem in venous thrombosis?

A

Fibrin

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6
Q

What are the three components of virchow’s triad?

A

Stasis
Vessel wall damage
Hypercoaguability

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7
Q

What side of the hear is under strain if there is a PE?

A

Right

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8
Q

What are the risk factors for a DVT?

A
Age
Marked obesity
Pregnancy
Puerperium
Oestrogen therapy
Previous DVT/PE
Trauma/Surgery
Malignancy
Paralysis
Infection
Thrombophilia
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9
Q

Why is age a major risk factor for a DVT?

A

Valves don’t function as well as you get older.

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10
Q

What hormone raises the risk of a DVT?

A

Oestrogen

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11
Q

Familial or acquired disorders of the haemostatic mechanism which are likely to predispose to thrombosis.

A

Thrombophillia

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12
Q

What protein is responsible for switching of thrombin formation?

A

Anti thrombin 3

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13
Q

What does anti thrombin 3 do?

A

Switch of thrombin formation

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14
Q

What happens if you have a Factor V Leiden Mutation?

A

More likely to have a VTE (Factor 5 isn’t switched off as easily)

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15
Q

What are the 5 main hereditary thrombophilias?

A
Factor V Leiden
Prothrombin 20210 mutation
Antithrombin deficiency
Protein C deficiency
Protein S deficiency
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16
Q

When should you consider testing someone for a hereditary thrombophilia?

A

Venous thrombosis

17
Q

How do you manage hereditary thombophilia?

A
  • Advice of avoiding risk
    (eg avoid COCP)
    Heparin at high risk times eg after surgery, after delivery
  • Long term anticoagulation for thoses at highest risk of multiple events (usually after they have had one!) with heparin or warfarin.
18
Q

A patient aged 40 has had a TIA. She has also had a DVT in the past and 3 miscarriages.

A

Antiphospholipid syndrome

19
Q

Does having antiphospholipid antibodies activate primary or secondary haemostasis, or both?

A

Both

20
Q

What is the APPT like in antiphospholipid syndrome?

A

Prolonged

21
Q

Where is there a conformational change in antiphospholipid syndrome?

A

Beta 2 glycoprotein