Flashcards in Venous Thrombosis Deck (21):
Is it platelets or fibrin than are the problem in arterial thrombosis?
Are arterial thrombi venous or platelet rich?
What are the tretament for arterial thrombus prevention?
Aspririn and other anti platelet drugs?
Are venous thrombus rich in platelets or fibrin?
Is it platelets or fibrin than are the problem in venous thrombosis?
What are the three components of virchow's triad?
Vessel wall damage
What side of the hear is under strain if there is a PE?
What are the risk factors for a DVT?
Why is age a major risk factor for a DVT?
Valves don't function as well as you get older.
What hormone raises the risk of a DVT?
Familial or acquired disorders of the haemostatic mechanism which are likely to predispose to thrombosis.
What protein is responsible for switching of thrombin formation?
Anti thrombin 3
What does anti thrombin 3 do?
Switch of thrombin formation
What happens if you have a Factor V Leiden Mutation?
More likely to have a VTE (Factor 5 isn't switched off as easily)
What are the 5 main hereditary thrombophilias?
Factor V Leiden
Prothrombin 20210 mutation
Protein C deficiency
Protein S deficiency
When should you consider testing someone for a hereditary thrombophilia?
How do you manage hereditary thombophilia?
- Advice of avoiding risk
(eg avoid COCP)
Heparin at high risk times eg after surgery, after delivery
- Long term anticoagulation for thoses at highest risk of multiple events (usually after they have had one!) with heparin or warfarin.
A patient aged 40 has had a TIA. She has also had a DVT in the past and 3 miscarriages.
Does having antiphospholipid antibodies activate primary or secondary haemostasis, or both?
What is the APPT like in antiphospholipid syndrome?