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Flashcards in Venous Thrombosis Deck (21):
1

Is it platelets or fibrin than are the problem in arterial thrombosis?

Platelets

2

Are arterial thrombi venous or platelet rich?

Platelet

3

What are the tretament for arterial thrombus prevention?

Aspririn and other anti platelet drugs?

4

Are venous thrombus rich in platelets or fibrin?

Fibrin

5

Is it platelets or fibrin than are the problem in venous thrombosis?

Fibrin

6

What are the three components of virchow's triad?

Stasis
Vessel wall damage
Hypercoaguability

7

What side of the hear is under strain if there is a PE?

Right

8

What are the risk factors for a DVT?

Age
Marked obesity
Pregnancy
Puerperium
Oestrogen therapy
Previous DVT/PE
Trauma/Surgery
Malignancy
Paralysis
Infection
Thrombophilia

9

Why is age a major risk factor for a DVT?

Valves don't function as well as you get older.

10

What hormone raises the risk of a DVT?

Oestrogen

11

Familial or acquired disorders of the haemostatic mechanism which are likely to predispose to thrombosis.

Thrombophillia

12

What protein is responsible for switching of thrombin formation?

Anti thrombin 3

13

What does anti thrombin 3 do?

Switch of thrombin formation

14

What happens if you have a Factor V Leiden Mutation?

More likely to have a VTE (Factor 5 isn't switched off as easily)

15

What are the 5 main hereditary thrombophilias?

Factor V Leiden
Prothrombin 20210 mutation
Antithrombin deficiency
Protein C deficiency
Protein S deficiency

16

When should you consider testing someone for a hereditary thrombophilia?

Venous thrombosis

17

How do you manage hereditary thombophilia?

- Advice of avoiding risk
(eg avoid COCP)
Heparin at high risk times eg after surgery, after delivery
- Long term anticoagulation for thoses at highest risk of multiple events (usually after they have had one!) with heparin or warfarin.

18

A patient aged 40 has had a TIA. She has also had a DVT in the past and 3 miscarriages.

Antiphospholipid syndrome

19

Does having antiphospholipid antibodies activate primary or secondary haemostasis, or both?

Both

20

What is the APPT like in antiphospholipid syndrome?

Prolonged

21

Where is there a conformational change in antiphospholipid syndrome?

Beta 2 glycoprotein