Vessels II- Vasculitis Flashcards Preview

Pathology exam 2 > Vessels II- Vasculitis > Flashcards

Flashcards in Vessels II- Vasculitis Deck (25):
1

vasculitis

inflammatory disease of blood vessel walls. immune mediated or infection mediated

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immune mediated vasculitis examples

giant cell, polyarteriitis nodes, granulomatosis with polyaingitis , microscopic polyangiitis- all affect different sized vessels

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infections vasculiitis

direct vascular invasion (syphillis, funds, septic) lead to weakened wall, which can cause aneurysm, thrombosis, infarct

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immune mediated mechanisms (4)

immune complex, anti neutrophil cytoplasmic antibodies (ANCA), anti endothelial cell antibodies, auto reactive T cells

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immune complex

presence of autoantibodies, can be to antigens in viral, drug hypersensitiveness, food. example of related disease is lupus

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anti neutrophil cytoplasmic antibodies

antibodies against the granules in neutrophils

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anti endothelial cell antibodies

what it sounds like, unsure what is the feature being attacked

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auto reactive T cells

often leads to granulomas

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giant cell

chronic vasculitis of large arteries, granulomatous inflammation, T cell mediated, more common in women (elderly). clinical presentation is VAGUE. Treat with Steroids! Fragmented Lamina

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giant cell morphology

nodular intimal thickening, fragmented lamina, patchy segments

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polyarteriitis odosa

immune complex, necrotizing, small and med. 1/3 cases have hep B infection. Renal, heart, liver, not pulmonary circulation. ischemia and infarction from impaired perfusion.. Symptoms often EPOSIDIC.

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morphology of polyarteriitis odosa

segments, often at branch points. inflammation can lead to aneurysm, impaired perfusion, ulceration, fibroid necrosis, ALL STAGES CO EXIST> recurrent, continuous infection

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microscopic polyangiitis

HyperS, Leukocyto, ANCAS

necrotizing, usually capillaries. All lesions are same age. GLOMERULITIS- pouci immune injury. fibrinoid necrosis of media. can lead to ANCAS/immune complexes

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granulomatosis with polyangiitis

necrotizing with train, upper RT involved. cause is often inhaled agent. antibodies present, renal disease serious complication

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triad of polyangiitis

necrotizing tissue, vasculitis, renal disease with increased CRP

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varicose veins

dialated, tortuous, increased pressure with decreased support. usually do not clot but may erode. pain, skin changes, and ulcers common

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hemangioma

benign blood vessel tumors

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types of hemangioma

capillary, juvenile, pyogenic, cavernous

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capillary hemangioma

skin, sub cut, mucus membranes

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juvenile hemangioma

skin, usually go away

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pyogenic hemangioma

skin, gingiva, oral, ulcerated

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cavernous hemangioma

DO NOT REGRESS

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angiosarcoma

aggressive, chemical carcinogens

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granulomatosis with polyangiitis triad

necrotizing tissue of respiratory tract, vasculitis of small/med vessels often in lung, renal disease (glomeruliitis)

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bloodiest for granulomatosis with polyangiitis

CRP/ anti prtoeinase 3 ANCAs