VIII - Topnotch Pharma Flash Cards - GI Drugs Preview

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Flashcards in VIII - Topnotch Pharma Flash Cards - GI Drugs Deck (25):
1

Neutralize stomach acid by reacting with protons in the lumen

Antacids (TOPNOTCH)

2

Impairs absorption of tetracyclines, flouroquinolones,itraconazole and iron

Antacids (TOPNOTCH)

3

Antacids

Magnesium-Aluminum Hydroxide, Calcium carbonate, Sodium bicarbonate (TOPNOTCH)

4

Competitive pharmacologic block of H2 receptors ; for peptic ulcer disease, Zollinger-Ellison syndrome, Gastroesophagal reflux, dyspepsia

H2 Receptor Blockers (TOPNOTCH)

5

H2 Receptor Blockers

Cimetidine, Ranitidine, Famotidine, Nizatidine (TOPNOTCH)

6

Highly effective in suppressing nocturnal acid secretion but only modest effect on meal- stimulated secretion

H2 Receptor Blockers (TOPNOTCH)

7

Irreversible blockade of H/K ATPase in active gastric panetal cells. Long lasting reduction of meal stimulated and nocturnal acid secretion

Proton Pump Inhibitors (TOPNOTCH)

8

Proton Pump Inhibitors

Omeprazole, Lansopraole, Rabeprazole, Pantoprazole, Esomeprazole (TOPNOTCH)

9

usually enetric coated, needs 3-4 days treatment to achieve full effectiveness

Omeprazole, Lansopraole, Rabeprazole, Pantoprazole, Esomeprazole (TOPNOTCH)

10

SE: Diarrhea, headache, abdominal pain, Malaabsorption (Vit B12, Ca, Fe, Zn), Infections (respiratory, enteric), Hypergastrinemia, Atrophic gastritis

Omeprazole, Lansopraole, Rabeprazole, Pantoprazole, Esomeprazole (TOPNOTCH)

11

Binds to injured tissue and forms a protective covering with ulcer beds. Accelerates healing of peptic ulcers and reduces recurrence rate

Sucralfate (TOPNOTCH)

12

Forms a protective coating on ulcerated tissue. Stimulates mucosal protective mechanisms, direct antimicrobial effects and sequestration of enterotoxins

Bismuth Salicylate (TOPNOTCH)

13

SE: Abdominal pain, Diarrhea, Uterine cramping, Miscarriage

Misoprostol (TOPNOTCH)

14

Activates EP receptors. Causes incresed HCO3 and mucus secretion in stomach. Uterine contraction

Misoprostol (TOPNOTCH)

15

SE: Black stools, darkening of tongue, Encephalopathy (Atraxia, headaches, confusion, seizures)

Bismuth Salicylate (TOPNOTCH)

16

Increases gastric emptying and intestinal motility

Metoclopramide, Domperidone, Erythromycin (TOPNOTCH)

17

______ and ______ block D receptors ; _______ stimulates motilin receptors

Metoclopramide and domperidone, Erythromycin (TOPNOTCH)

18

T or F: Domperidone does not cross the BBB (less toxic)

TRUE (TOPNOTCH)

19

Indigestible, hydrophilic colloids that absorb water, forming a bulky emollient gel that distends the colon and promotes peristasis

Bulk-forming Laxatives: Psyllium, Methylcellulose, Polycarbophil (TOPNOTCH)

20

Soften stool material, Permitting water and lipids to penetrate

Stool-softener: Docusate, Glycerine, Suppository, Mineral oil (TOPNOTCH)

21

Soluble but nonabsorbable compound that result in increased stool liquidity due to an obligate increase in fecal fluid

Osmotic Laxatives: Lactulose, Magnesium oxide, Sorbitol, Magnesium citrate, Sodium phosphate, Polyethylene Glycol (TOPNOTCH)

22

Directly stimulate enteric nervous system and colonic electrolyte and fluid secretion

Stimulant Laxatives: Bisacodyl, Aloe, Senna, Cascara, Castor oil (TOPNOTCH)

23

Activates opioid receptors in enteric nervous system. Slows motility with negligible CNS effects

Diphenoxylate, Loperamide, Kaolin+Pectin, Colloidal Bismuth (TOPNOTCH)

24

Blocks chemoreceptor trigger zone and enteric nervous system 5-HT3 receptors ; For Vomiting (Post chemothereaphy, postoperative)

Ondansetron, Granisetron, Dolasetron, Palonosetron (TOPNOTCH)

25

Probably inhibits production of eicosanoid inflammatory mediators ; for Inflammatory bowel disease (mild to moderate)

Mesalamine, Balsalazide, Olsalazine, Sulfasalazine (TOPNOTCH)