Viral Diarrhea Flashcards Preview

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Flashcards in Viral Diarrhea Deck (15):
1

structure/genome of astrovirus

targets of sporadic and outbreaks of infection?

naked, icosahedral, ssRNA(+)

sporadic infection in children

outbreaks in any age; >70% of adults have antibody

2

all relavent viruses causing diarrhea

rotavirus

enteric adenovirus

astrovirus

caliciviruses(norovirus, sapovirus)

2

serotypes of adenovirus causing gastroenteritis

serotypes 40 and 41

3

most likely cause of acute outbreak of nonbacterial gastroenteritis

caliciviruses

4

pathogenesis of rotavirus

blunts microvillie

decreases absorption

inhibits disaccharide absorption

inflammation

5

enteric adenovirus primarily affects who?

children

4-10% of sporadic diarrhea in children is caused by enteric adenovirus

6

structure/genome of rotavirus

naked, icosahedral dsRNA(11 segments; can rearrange)

 

dsRNA is unique to rotavirus

7

increased risk of diarrheal infection for O blood type

which virus?

norovirus(a calicivirus)

8

rotavirus symptoms, duration

HANVD w/low grade fever

lasts 4-8 days; about a week

9

vaccines for diarrheal virus

rota Teq

Rotarix

ROTAVAC

 

can be 90% effective against severe; 70-80% for regular

ROTAVIRUS

11

function of VP7, VP4, VP6, NSP4 in rotavirus

VP7 - cleaved in stomach to activate virus; surface protein

VP4 - allows attachmentto epithelial cells in smal lintestine after activation

VP6 - inner capsid protein; diagnostic antigen

NSP4 - enterotoxin, causes chloride secretion/diarrhea

12

seasonality for rotavirus, noravirus

winter peak

13

difference between enteric adenovirus and rotavirus infections?

enteric adenoviruses can last 5-12 days; a little longer than rotavirus(4-8)

14

duration/incubation for calicivirus

1-2 days for incubation

1-2 days for duration

15

most common cause of severe diarrhea in children

 

rotavirus