Viral genetics Flashcards
(19 cards)
Viral polymerases are known to be
error prone and generate many mutations during replication of the genome
RNA viruses lack ?
genetic error-checking mechanism (proofreading)
the rates of mutation for DNA viruses is (higher/lower) than RNA
Lower
Define viral mutation
permanent change in the DNA base sequence, new virus strains with properties different from the parental (wild-type virus)
Outcomes of viral mutation mostly are?
No effect
Define lethat mutations
mutations in essential genes can inactivate the virus
Define attenuated mutants
cause less serious disease in animals or humans
Define host range mutants
differ in the tissue type or species that can be infected
Define drug-resistant mutants
resistant to antiviral drug
Example of altering in the antigenicity of the virus
influenza drift
Give an example of Conditional lethal mutations
temperature-sensitive Influenza virus mutants
Genetic interaction between viruses means
genetic exchange between viruses or the virus and the host
Diff between Antigenic shift and genetic driftb
-major change/minor change
-reassortment of RNA segment/mutation in the genome RNA
Define vector
vehicle to deliver genetic material into cells
Viral vectors in Gene therapy
Deliver functional gene into patient with genetic disease
Viral vectors in Gene therapy example
retrovirus used as a vector to introduce Adenosine deaminase gene into cells of patients with SCID
Viral vector vaccines is a modified version of?
a modified version of one virus (vector) is used to deliver a nucleic acid coding for an antigen for another infectious agent into a cell
Example of Viral vector vaccines
Viral vector covid-19 vaccines
Does Viral vector vaccines causes infection? Explain
Viral vector vaccines do not cause infection with either the virus used as the vector, or the source of the antigen
