Virology: Hepatitis & HIV Flashcards Preview

First Aid: Microbiology > Virology: Hepatitis & HIV > Flashcards

Flashcards in Virology: Hepatitis & HIV Deck (31):
1

Hepatitis 

fecal-oral transmission

HAV

HEV

2

Hepatitis 

parenteral, sexual, maternal-fetal transmission

HBV

HDV

3

Hepatitis 

primarily blood transmission

HCV

IVDU, post-transfusion

4

signs/symptoms of all hepatitis viruses

  • fever
  • jaundice
  • increased ALT & AST

5

RNA picornavirus 

HAV

6

DNA hepadnavirus

HBV

7

RNA flavivirus

HCV

8

RNA delta virus 

HDV

9

RNA hepevirus 

HEV

10

3 A's of HAV

  • Asymptomatic 
  • Acute
  • Alone (no carriers)

11

4 C's of HCV

  • Chronic
  • Cirrhosis
  • Carcinoma
  • Carrier 

12

2 D's of HDV

  • Defective virus
  • Dependent on HBV
    • superinfection decreases prognosis 

13

3 E's of HEV

  • Enteric 
  • Expectant mothers
  • Epidemic 

14

Anti-HAV (IgM)

IgM antibody to HAV

best test to detect active hepatitis A

15

Anti-HAV (IgG)

  • IgG antibody indicates prior HAV infection and/or prior vaccination
  • protects against reinfection

16

HBsAg

antigen found on surface of HBV

indicates hepatitis B infection

17

Anti-HBs

Antibody to HBsAg

indicates immunity to hepatitis B

18

HBcAg

antigen associated w/ core of HBV

19

Anti-HBc 

  • antibody to HBcAg
  • IgM = acute/recent infection
  • IgG = prior exposure or chronic infection 
  • positive during window period 

20

HBeAg

indicates active viral replication

high transmissibility 

21

Anti-HBe

antibody to HBeAg

low transmissibility 

22

3 structural genes of HIV

  • env 
    • gp120 = attachment to host CD4+ T-cell
    • gp41 = fusion & entry 
  • gag (p24) - capsid protein 
  • pol - reverse transcriptase, aspartate protease, integrase 

23

HIV virus binds ______ (early) or _____ (late) co-receptor & CD4 on T-cells.

Binds ____ & CD4 on macrophages.

CCR5

CXCR4

CCR5

24

HIV

  • homozygous CCR5 mutation
  • heterozygous CCR5 mutation

  • homozygous CCR5 mutation = immunity
  • heterozygous CCR5 mutation = slower course

25

4 stages of untreated HIV infection

  • Flu-like (acute)
  • Feeling fine (latent)
  • Falling count 
  • Final crisis 

26

systemic diseases of HIV+ adults 

Histoplasma capsulatum 

  • low-grade fevers
  • cough
  • hepatosplenomegaly
  • tongue ulcer 

27

dermatologic diseases of HIV+ adults

  • Fluffy white cottage cheese lesions
    • C. albicans
  • Hairy leukoplakia
    • EBV
  • Superficial vascular proliferation 
    • Bartonella henselae 

28

gastrointestinal diseases of HIV+ adults

  • chronic, watery diarrhea
  • Cryptosporidium spp.

29

neurologic diseases of HIV+ adults 

  • Abscesses
    • Toxoplasma gondii 
  • Dementia
    • HIV-associated
  • Encephalopathy 
    • JC virus reactivation
  • Meningitis
    • Cryptococcus neoformans
  • Retinitis 
    • CMV

30

oncologic disease of HIV+ adults 

  • Non-Hodgkin lymphoma (large cell)
    • EBV
  • Primary CNS lymphoma
    • EBV
  • SCC
    • HPV
  • Superficial neoplastic proliferation of vasculature
    • HHV-8 

31

respiratory disease of HIV+ adults 

  • Interstitial pneumonia 
    • CMV
  • Invasive aspergillosis 
    • Aspergillus fumigatus 
  • Pneumocystis pneumonia
    • PCP
  • Pneumonia
    • S. pneumoniae 
  • TB-like disease 
    • Mycobacterium avium-intracellulare