Virology: Intro & DNA Viruses Flashcards Preview

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Flashcards in Virology: Intro & DNA Viruses Deck (42):
1

exchange of genes btwn 2 chromosomes 

crossing over 

recombination 

2

viruses w/ segmented genomes exchange segments

high frequency 

reassortment 

*influenza pandemics* 

3

1 of 2 viruses the infect the cell has a mutation

nonfunctional protein 

 

complementation

*nonmutated virus complements the mutated one*

4

simultaneous infections of a cell w/ 2 viruses

genome of virus A coated w/ surface proteins of B

determines tropism of hybrid virus 

phenotypic mixing 

5

Vaccines

induce humoral & cell-mediated immunity

reverted to virulence rarely 

live attenuated vaccines

6

which viruses use live-attenuated vaccines

  • Smallpox
  • Yellow fever
  • Chickenpox
  • Sabin polio virus
  • MMR (measles, mumps, rubella)
  • Influenza 

7

which viruses use killed vaccines

  • Rabies
  • Influenza 
  • Salk Polio 
  • HAV

8

which viruses use recombinant vaccines

  • HBV
  • HPV (6, 11, 16, 18)

9

all DNA viruses except ___________ are dsDNA

Parvoviridae 

10

all DNA viruses are linear except......

circular

  • papillomavirus
  • polyomavirus
  • hepadnavirus 

11

all RNA viruses except _______ are ssRNA

Reoviridae 

12

positive stranded RNA viruses

  • retrovirus
  • togavirus
  • flavivirus
  • coronavirus
  • hepevirus
  • calicivirus
  • picornavirus 

13

purified nucleic acids of most __DNA & __strand __RNA viruses are infectious 

dsDNA

(+) strand

ssRNA

14

all DNA viruses replicate in the ______

*except poxvirus*

nucleus

15

all RNA viruses replicate in the ______

*except influenza virus & retroviruses*

cytoplasm

16

Naked (nonenveloped) viruses 

  • Papillomavirus 
  • Adenovirus
  • Parvovirus
  • Polyomavirus
  • Calicivirus
  • Picornavirus
  • Reovirus
  • Hepevirus 

17

DNA virus characteristics 

HHAPPPPy viruses

  • Hepadnavirus
  • Herpesvirus
  • Adenovirs
  • Poxvirus
  • Parvovirus
  • Papillomavirus
  • Polyomavirus

18

all DNA viruses are icosahedral except ______

pox (complex)

19

acute or chronic hepatitis 

Hepadnavirus (HBV)

20

clinical diseases of Adenovirus 

  • Febrile pharyngitis (sore throat)
  • Acute hemorrhagic cystitis 
  • Pneumonia 
  • Conjunctivitis ("pink eye")

21

clinical presentation of Parvovirus (B19)

  • Aplastic crisis in sickle cell disease
  • "slapped cheeks" rash in children 
    • Erythema infectiosum (5th disease)
  • RBC destruction in fetus 
    • Hydrops fetalis, death 
  • Pure RBC aplasia
  • RA-like symptoms in adults 

22

clinical presentation of Papillomavirus (HPV)

  • warts (1, 2, 6, 11)
  • CIN
  • cervical cancer (16, 18)

23

clinical presentation of Polyomavirus (JC virus) 

progressive multifocal leukoencephalopathy in HIV

24

clinical presentation of Polyomavirus (BK virus)

transplant patients 

targets kidney 

25

clinical presentation of Poxvirus 

  • Smallpox
  • Cowpox
  • Molluscum contagiosum 

26

flesh-colored dome lesions 

central umbilicated dimple

Molluscum contagiosum 

27

clinical disease of HSV-1

  • gingivostomatitis 
  • keratoconjunctivitis 
  • temporal lobe encephalitis 
  • herpes labialis 

28

HSV-1 transmission

latent in trigeminal ganglia 

transmission by respiratory secretions, saliva 

29

clinical disease of HSV-2

  • Herpes genitalis
  • Neonatal herpes

30

HSV-2 transmission 

latent in sacral ganglia

transmitted by sexual contact, perinatally 

31

clinical disease of VZV

  • Varicella-zoster (chickenpox, shingles)
  • Encephalitis 
  • Pneumonia 
  • complication: post-herpetic neuralgia 

32

VZV transmission

latent in dorsal root or trigeminal ganglia 

transmitted by respiratory secretions 

33

mononucleosis characteristics 

EBV

  • fever
  • hepatosplenomegaly 
  • pharyngitis 
  • lymphadenopathy (posterior cervical nodes)

34

EBV

transmission

infection

test 

  • respiratory secretions, saliva ("kissing disease")
  • infects B-cells
  • (+) monospot test 

35

associated w/ Hodgkin lymphoma, endemic Burkitt lymphoma, nasopharyngeal carcinoma 

EBV

36

clinical disease of CMV

  • congenital infection
  • mononucleosis
  • pneumonia
  • retinitis 

37

"owl eye" inclusions 

CMV

38

CMV transmission

latent in mononuclear cells 

congenital, transfusion, sexual contact, saliva, urine, transplant 

39

HHV-6

clinical presentation

transmission

  • Roseola
    • high fevers for several days
    • seizures
    • diffuse macular rash 
  • transmitted by saliva 

40

HHV-8 

clinical presentation

patient population 

  • Kaposi sarcoma - neoplasm of endothelial cells
  • HIV/AIDS & transplant patients 

41

HHV-8

what skin looks like 

other organs

transmission

  • dark/violaceous flat & nodular skin lesions
  • endothelial growths 
  • GI tract & lungs
  • transmitted by sexual contact 

42

HSV identification

  • skin/genitalia
  • herpes encephalitis 
  • genital herpes

intranuclear Cowdry A inclusions

  • viral culture 
  • CSF PCR
  • Tzanck test