W23-L6: Drug Dependence and Anti-Depressants Flashcards Preview

Matt's Block 06 - Neuro block > W23-L6: Drug Dependence and Anti-Depressants > Flashcards

Flashcards in W23-L6: Drug Dependence and Anti-Depressants Deck (14):
1

What is drug dependence?

State where drug use becomes compulsive taking precedence over other needs arises

2

What is drug abuse?

Use of illicit substances (or illicit use of legal substances) characterised by recurrent and clinically significant adverse consequenses

3

Why are drugs abused?

-Rewarding effect of the psychoactive drug
-Habituation or adpatation

4

What are key transmitters in the dopaminergic reward pathways?

•Acetylcholine, Serotonin,
Noradrenaline
• GABA, Glutamate
• Opioids

5

How do amphetamines develop dependence?

Related to dopaminergic actions in nuclear accumbens

6

How does LSD work?

Agonist at 5-HT2 receptors, activates autoreceptors on 5-HT neurones in Raphe

7

What type of drug is caffeine?

Adenosine antagonist, phosphodiesterase inhibitor

8

How does ethanol work?

CNS depressant can:
• Inhibit Ca++ channel opening
• Enhance GABA action
• Inhibit glutamate receptors

9

How many generations of anti-depressant drugs are there?

Three

10

What were the first generation of anti-depressants?

Tricyclic and Monoamine oxidase inhibitors

11

How do Tricyclic antidepressants work?

Inhibit neuronal uptake of noradrenaline and serotonin

12

How do Monoamine oxidase inhibitors work?

Increase levels of 5HT, NA and DA

13

What are the second generation of anti-depressant drugs?

Selective serotonin uptake inhibitors and Selective serotonin/noradrenaline uptake inhibitors

14

What are the third generation anti-depressants

Novel monoaminergic drugs and Non-monoaminergic drugs

Decks in Matt's Block 06 - Neuro block Class (48):