W23-L9: Viruses Affecting the Nervous System Flashcards Preview

Matt's Block 06 - Neuro block > W23-L9: Viruses Affecting the Nervous System > Flashcards

Flashcards in W23-L9: Viruses Affecting the Nervous System Deck (26):
1

Neurotrophic virus

capable of replicating in nerve cells

2

Neuroinvasive virus

capable of entering or infecting the central nervous system

3

Neurovirulent virus

capable of causing disease within the nervous system

4

What is myelitis?

an infection of the spinal cord

5

What is Encephalomyelitis?

When both the brain and the spinal cord become inflamed

6

Primary viral encephalitis

direct viral infection of the spinal cord and brain. Can be focal or diffuse.

7

Secondary encephalitis

results from complications of a current viral infection where virus spreads to the brain, usually via the blood.

8

What is the main cause of viral meningitis?

Enterovirus

9

What is the main cause of viral encephalitis?

Herpes Simplex Virus type 1 and 2

10

What is Guillain-Barre syndrome?

Is an acute inflammatory demyelinating disease following infection with several viruses such as EBV

11

What is Reye's syndrome?

Post-infection with influenza or chickenpox in children

12

Why are viruses protected from attack by cytotoxic T cells when within peripheral nerves?

nerve cells do not have class I molecules

13

Where does replication of viruses take place within nerves?

takes place in the body of nerve as this is where protein synthesis takes place

14

Can released progeny cross synaptic junctions?

Yes

15

Where does coronavirus and herpes simplex virus enter the brain?

Olfactory Bulb

16

Viruses that directly kill neurones cause?

Inflammatory

17

Features of the rabies virus?

Bullet shaped -ve stranded RNA virus with a helical capsid and an envelope

18

How invasive and virulent is the rabies virus?

Highly

19

What is part of the growth cycle of rabies virus?

Growth in nerve cells is an obligatory part of the life cycle of the virus

20

What is the pathogenesis of rabies?

• Aggression
• Thirst but muscle spasm and terror upon attempt to drink water

21

What is the treatment of rabies virus?

can vaccinate after infection as it takes a while to get to the brain

22

How invasive and virulent is the alpha herpesviruses virus?

Low neuroinvasiveness and high neurovirulence

23

How does herpes simplex type 1 enter the body?

Contact with infected saliva

24

What does Varicella zoster virus cause?

chicken pox (varicella) and shingles (zoster)

25

T/F Growth in nerve cells is NOT an obligatory part of the life cycle of Varicella zoster virus

True

26

What is poliovirus pathogenesis?

Poliovirus travels in the blood as free virus and can target the motor neuron cells in the anterior horn leading to paralysis

Decks in Matt's Block 06 - Neuro block Class (48):