Flashcards in W4 Protein Synthesis Inhibitors Deck (8)
Loading flashcards...
1
Oxazolidinones
Mechanism
Spec
Resistance
Adverse
- Linezolid
- bacteriostatic-- + incl. MRSA, vanco resistant Enterococci
- 23S alterations
- bone marrow suppression, serotonin syndrome
2
Aminoglycosides
Tobramycin, Gentamicin, Amikacin
Mechanism
Spec
Resistance
Adverse
- prevent initial complex formation
- (-) aerobic
- cell wall/drug alteration
- nephrotoxicity, ototoxicity, XXX PREGNANCY
3
Tetracyclines
Tetracycline, Doxycycline, Minocycline
Mechanism
Spec
Resistance
Adverse
- X attachment of tRNA onto 30S
- M. pneumonia, H. phlori (Lyme disease)
- increased efflux
- side effects:
- chelates: bad absorption
- photosensitivity
- bad teeth/bone growth
- XXX PREGNANCY
- chelates: bad absorption
- photosensitivity
- bad teeth/bone growth
- XXX PREGNANCY
4
Chloramphenicols
Chloramphenicol
Mechanism
Spec
Resistance
Adverse
- X peptide bond formation, 50S
- extended
- drug aceylation
- bone marrow suppression, aplastic anemia
5
Macrolides
Erythromycin, Azithromycin, Clarithromycin
Mechanism
Spec
Resistance
Adverse
- X translocation, 50S
- chlamydia, upper respiratory tract
- binding site mod, inc. efflux
- Cyt P450 inhibitor
- CLARITHROMYCIN XXX PREGNANCY
- CLARITHROMYCIN XXX PREGNANCY
6
Lincosamide
Clindamycin
Mechanism
Spec
Resistance
Adverse
- X translocation, 50S
- + aerobic, acne
- binding site change, drug alteration
-
C. diff superinfection
7
Streptogrammins
Quinupristin, Dalfopristin
Mechanism
Spec
Resistance
Adverse
- X translocation
- multidrug resistant G+ bacteria
- drug site modification, more efflux
- Cyt P450 inhibitor
8
