W4 Protein Synthesis Inhibitors Flashcards Preview

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Flashcards in W4 Protein Synthesis Inhibitors Deck (8)
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1

Oxazolidinones

Mechanism

Spec

Resistance

Adverse

  • Linezolid
  • bacteriostatic-- + incl. MRSA, vanco resistant Enterococci
  • 23S alterations
  • bone marrow suppression, serotonin syndrome

2

Aminoglycosides

Tobramycin, Gentamicin, Amikacin

Mechanism

Spec

Resistance

Adverse

  • prevent initial complex formation
  • (-) aerobic
  • cell wall/drug alteration
  • nephrotoxicity, ototoxicity,  XXX PREGNANCY

3

Tetracyclines

Tetracycline, Doxycycline, Minocycline

Mechanism

Spec

Resistance

Adverse

  • X attachment of tRNA onto 30S
  • M. pneumonia, H. phlori (Lyme disease)
  • increased efflux
  • side effects:
    • chelates: bad absorption
    • photosensitivity
    • bad teeth/bone growth
    • XXX PREGNANCY

4

Chloramphenicols

Chloramphenicol

Mechanism

Spec

Resistance

Adverse

  • X peptide bond formation, 50S
  • extended
  • drug aceylation
  • bone marrow suppression, aplastic anemia

5

Macrolides

Erythromycin, Azithromycin, Clarithromycin

Mechanism

Spec

Resistance

Adverse

  • X translocation, 50S
  • chlamydia, upper respiratory tract
  • binding site mod, inc. efflux
  • Cyt P450 inhibitor
    • CLARITHROMYCIN XXX PREGNANCY

6

Lincosamide

Clindamycin

Mechanism

Spec

Resistance

Adverse

  • X translocation, 50S
  • + aerobic, acne
  • binding site change, drug alteration
  • C. diff superinfection

7

Streptogrammins

Quinupristin, Dalfopristin

Mechanism

Spec

Resistance

Adverse

  • X translocation
  • multidrug resistant G+ bacteria
  • drug site modification, more efflux
  • Cyt P450 inhibitor

8