W4 Protein Synthesis Inhibitors Flashcards Preview

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Flashcards in W4 Protein Synthesis Inhibitors Deck (8)
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1
Q

Oxazolidinones

  • Mechanism*
  • Spec*
  • Resistance*
  • Adverse*
A
  • Linezolid
  • bacteriostatic– + incl. MRSA, vanco resistant Enterococci
  • 23S alterations
  • bone marrow suppression, serotonin syndrome
2
Q

Aminoglycosides

Tobramycin, Gentamicin, Amikacin

  • Mechanism*
  • Spec*
  • Resistance*
  • Adverse*
A
  • prevent initial complex formation
  • (-) aerobic
  • cell wall/drug alteration
  • nephrotoxicity, ototoxicity, XXX PREGNANCY
3
Q

Tetracyclines

Tetracycline, Doxycycline, Minocycline

  • Mechanism*
  • Spec*
  • Resistance*
  • Adverse*
A
  • X attachment of tRNA onto 30S
  • M. pneumonia, H. phlori (Lyme disease)
  • increased efflux
  • side effects:
    • chelates: bad absorption
    • photosensitivity
    • bad teeth/bone growth
    • XXX PREGNANCY
4
Q

Chloramphenicols

Chloramphenicol

  • Mechanism*
  • Spec*
  • Resistance*
  • Adverse*
A
  • X peptide bond formation, 50S
  • extended
  • drug aceylation
  • bone marrow suppression, aplastic anemia
5
Q

Macrolides

Erythromycin, Azithromycin, Clarithromycin

  • Mechanism*
  • Spec*
  • Resistance*
  • Adverse*
A
  • X translocation, 50S
  • chlamydia, upper respiratory tract
  • binding site mod, inc. efflux
  • Cyt P450 inhibitor
    • CLARITHROMYCIN XXX PREGNANCY
6
Q

Lincosamide

Clindamycin

  • Mechanism*
  • Spec*
  • Resistance*
  • Adverse*
A
  • X translocation, 50S
    • aerobic, acne
  • binding site change, drug alteration
  • C. diff superinfection
7
Q

Streptogrammins

Quinupristin, Dalfopristin

  • Mechanism*
  • Spec*
  • Resistance*
  • Adverse*
A
  • X translocation
  • multidrug resistant G+ bacteria
  • drug site modification, more efflux
  • Cyt P450 inhibitor
8
Q
A