Wagner Day 18 Flashcards Preview

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Flashcards in Wagner Day 18 Deck (21):
1

S5, S6 and intervening loop do what?

collective interaction selective filter

2

Selective filter needs what two amino acids?

lysine at 1422, alanine 1712

3

ion pore is made up of

S5, S6 intervening loop

4

How many domains does Beta have?
in Na+ gate

1

5

how many domains does alpha have in Na+ gate

4 domains , 6 protiens in membrane for each domain

6

TTX inhibits which gate? and what amino acids are sensitive to it?

Na+ gate glutamate E387,tyrosine 385

7

Channel activation has S(4/5)
-Na+ gate

4

8

S4 alpha has which two amino asides
-in Na+gate

lysine and arginine

9

Inactivation determinants are from Domain (3/4/5)

Domain 3 and 4

10

Domain 3 and 4 have which amino acids?
is it for activation or inactivaitn

isoleucine, phenylalanine, methionine

11

for K gates what makes up the inactivation gate?

-N terminal or beta subunit with cytoplasmic loop that connects S4 and S5

12

(L/N/PandQ/T) highest rate of inactivation, lowest threshold

T

13

(L/N/PandQ/T) blocked by shellfish w conotoxins

L

14

(L/N/PandQ/T) blocked by spider toxins agatoxins

Pdn Q

15

(L/N/PandQ/T) -blocked by dihydropyridine drugs

L

16

Ca2+ gate has how many subunits and is it covalently bonded?

5 , yes

17

Glutamate in the Ca2+ channels does what?

-provides high affinity Ca2+ binding
-selective filter

18


5HT2 -> Gq
5-HT1 ->Gi/o
5HT3 receptor is a ligand-gated ion channel that allows Na+ and Ca2+ influx, and K+ efflux.
5HT4-7 receptor systems are poorly understood.

serotonin

19

M1, M3 & M5

Gq

20

M2 & M4

Gi

21

GABAB recptor

Gi/o