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Flashcards in Water & pH Deck (20):
1

Predominant chemical component of living organisms; Irregularly, slightly skewed tetrahedron - oxygen at center and 2 hydrogens at corners

Water

2

Percentage of Intracellular water

40% (2/3)

3

Percentage of Extracellular water

20% (1/3)

4

Percentage of Interstitial fluid

15%

5

Percentage of Blood Plasma

5%

6

Properties of Water

DipoleHigh dielectric constantForms hydrogen bondsExcellent nucleophileAmphoteric

7

Acts as both an acid and base

Amphoteric

8

Has hydrophilic and hydrophobic parts

Amphipathic

9

The negative log of hydrogen ion concentration; Measure alkalinity or acidity

pH

10

What is the normal pH of blood?

7.35-7.45

11

Proton donors

Acids

12

Proton acceptors

Bases

13

High H+Low pHLow pKa

Acids

14

Low H+High pHHigh pKa

Bases

15

Causes of High Anion Gap Metabolic Acidosis

MethanolUremiaDiabetic KetoacidosisParaldehyde and Propylene GlycolIsoniazidLactic Acidosis (Sepsis, Shock)Ethylene GlycolSalicylates

16

Used to calculate the concentration of a weak acid (HA) and its conjugate base (A-)

Henderson-Hasselbach Equation

17

pH

Protonated

18

pH>pKaAcid is chargedBase is uncharged

Unprotonated

19

Mixture of weak acid and its conjugate base that can resist a change in pH when protons are produced or consumed

Buffers

20

Physiologic Buffers

Bicarbonate (most important extracellular)Proteins (most important intracellular)Orthophosphate