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Flashcards in Wednesday Groupings/Definitions/Presentations Deck (51):
1

Lymphocytosis count

>4000

2

Lymphocytoses causes

infectious-EBV, CMV, hepatitis, etc
transient stress-trauma, MI, seizures

3

List the 5 neoplastic proliferations of mature lymphocytes

CLL
Hairy Cell Leukemia
Splenic marginal zone lymphoma
ATLL
Sezary syndrome

4

List the 7 lymphoid neoplasms we need to know

B-ALL
T-ALL
CLL/SLL
Hairy Cell
Large Granular lymphocytic leukemia
Mycosis fungoides/Sezary syndrome
ATLL

5

Name the precursor B-cell neoplasm

B-ALL

6

Name the 2 peripheral B-cell neoplasms

CLL/SLL
Hairy Cell

7

Name the precursor T-cell neoplasm

T-ALL

8

Name the peripheral T-cell and NK-cell neoplasms

large granular lymphocytic leukemia
mycosis fungoides/sezary syndrome
Adult T-cell leukemia/lymphoma

9

Key features of B-ALL

precursor B cells
kids
pancytopenia
aggressive

10

Key features of T-ALL

precursor T cells
adolescent males
thymic masses
aggressive
variable BM involvement

11

Key features of hairy cell

memory B cells
older males
pancytopenia
splenomegaly
indolent

12

Key features of CLL/SLL

naive B or memory B
older adults
BM, LN, spleen and liver disease
autoimmune hemolysis
thrombocytopenia (minority)
indolent

13

Key features of ATLL

caused by HTLV-1
helper T cells
adults with cutaneous lesions
BM involved
hypercalcemia
Japan, West Africa, Caribbean
aggressive (fatal months to a year)

14

Mycosis Fungoides/Sezary syndrome key features

helper t cells
adults
cutaneous patches/plaques/ etc
indolent

15

Large Granular lymphocytic leukemia

cytotoxic T and NK cell types
RARE
adults
splenomegaly
neutropenia
anemia
sometimes with AI diseases (Rheumatologic)

16

"starry sky appearance"

burkitt lymphoma

17

Are tumors with mutated or unmutated IG segments more aggresse?

those w/unmutated IG segments

18

What is MBUS?

monoclonal B cells of undetermined significance
asymptomatic that have CD5+Bcells inthe PB but too few to be CLL

19

Are tumors with mutated or unmutated IG segments more aggresse?

those w/unmutated IG segments

20

What is MBUS?

monoclonal B cells of undetermined significance
asymptomatic that have CD5+Bcells inthe PB but too few to be CLL

21

Factors the make CLL/SLL prognosis worse

11q/17p deletions
lack of somatic hypermutation
expression of ZAP70

22

What does ZAP-70 do?

augments signals produced by the Ig receptor

23

What is richter syndrome?

transformation from CLL/SLL to large B cell lymphoma/other more aggressive tumor

24

Lab findings of hairy cell leukemia?

hairlike projections
BM can't be aspirated "dry tap"

25

Sezary syndrome blood smear finding?

Cerebriform nuclei

26

What can HTLV-1 give rise to besides ATLL?

demyelinating disease of CNS and thoraco lumbar spinal cord

27

What type of genetic material do all retroviruses contain?

2 copies of single stranded +RNA

28

ATLL histology

flower cells
abnormally lobulated nuclei

29

What is TSP/HAM? Cause

Tropic spastic paraparesis/HTLV_1 associated myelopathy
HTLV-1

30

What is TSP/HAM? Cause

Tropic spastic paraparesis/HTLV_1 associated myelopathy
HTLV-1

31

Multiple Myeloma Key features

most common plasma cell neoplasm
malignant
osteolytic lesions/pathologic fractures
end organ damage
amyloidosis

32

What types of end organ damage are seen in multiple myeloma?

(CRAB)
hyperCalcemia
Renal insufficiency
Anema
Bone disease

33

What are the most common locations for lytic bone lesions in multiple myeloma?

vertebrae
ribs
skull
pelvis
femur

34

What is rouleaux and when is it seen?

red cells coining up on top of each other because there's too much protein around
seen in multiple myeloma

35

Main complication of multiple myeloma? Cause of death?

immunosuppression
recurrent infections COD

36

Multiple myeloma prognosis?

incurable
3yrs

37

What is MGUS?

monoclonal gammopathy of undetermined significance
benign but, precursor to multiple myeloma

38

What are plasmacytomas?

localized growth of monoclonal plasma cells
seen in Multiple Myeloma or as distinct entity

39

Where are most common plasmacytomas as distinct entities located?

upper respiratory tract

40

What is amyloid?

an extracellular proteinaceous misfolded substance

41

What is amyloidosis? most common forms?

disease characterized by deposition of amyloid
amyloid light chain, amyloid associated, beta amyloid

42

Lab finding for amyloidosis?

apple green birefringence on congo red stain

43

What does Primary amyloidosis produce? causes?

light chains (bence jones proteins)
plasma cell dyscrasia (MM or MGUS)

44

What gene is on 17p?

p53

45

Which age groups have worst prognosis with B-ALL?

<2
adults

46

Good genetic prognostics for B-ALL

hyperdiploidy
t(12,21)

47

Bad genetic prognostics for B-ALL

hypodiploidy
t(9,22)

48

Bad clinical prognostics for B-ALL

100,000
CSF involvement
marrow involvement by day 15

49

Good prognostic indicators CLL/SLL

mutated IG gene (post germinal)
deletion 13q

50

Bad prognostic indicators CLL/SLL

unmutated IG (pregerminal)
CD38/ZAP-70
deletion 11q, 17p

51

List the causes of atypical lymphocytes +/- lymphocytoses

CLL/SLL
Leukemic Lymphoma
Hairy Cell
ATLL
Sezary