Week 1 - Hematology Flashcards Preview

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Flashcards in Week 1 - Hematology Deck (17):
1

List possible causes of Vitamin B12 deficiency

Nutritional deficiency - vegetarianism/veganism
Pernicious anemia
Proton pump inhibitors

2

Discuss the link between folate/B12 deficiency and depression.

Low levels of folate or vitamin B12 can disrupt transmethylation reaction, leading to accumulation of homocysteine and impaired metabolism of neutrotransmitters, phospholipids, myelin, and receptors.

3

Hematocrit is __________

proportion of RBCs to plasma in the blood

4

List CBC normal values for: Hemoglobin, Hematocrit, WBC, RBC

Hemoglobin: 12-18g/dL
Hematocrit: 40-54% males, 37-47% (females)
WBC: 4,000 - 10,000/mm3
RBC: 4.6-6.2 million/microL males, 4.2-6.4 million/microL females

5

ESR can indicate _______ because _________

inflammatory disease

certain inflammatory diseases yield abnormal proteins that stick to RBCs causing them to settle out of plasma more rapidly

6

Normal range for fasting plasma glucose:

65-99mg/dL

7

Normal range for total cholesterol

100-199 mg/dL

8

High homocysteine levels can cause _________

1) cholesterol to change into oxidized LDL->artery damage
2) blood to clot more easily than it should -> blood vessel blockage

9

List non-specific signs and symptoms of anemia

weakness, fatigue, malaise, skin pallor, skin thining, skin elasticity, brittle nails, angina pectoris, headache, faintness, dim vision, vertigo, tinnitus

10

If anemia is suspected, the first consideration should be ________

blood loss

11

Anemia can be observed by inspecting ______

conjunctiva, gingiva, nail beds, tongue

12

Which test can indicate macrocytic or microcytic anemia?

MCV, peripheral blood smear

13

Macrocytic hypochromic anemia can indicate ________

folate or B12 deficiency

14

Microcytic hypochromic anemia can indicate _______

iron deficiency

15

What will be uniquely present in the blood in B12 deficiency due to pernicious anemia?

Anti-intrinsic factor antibodies

16

What test should be conducted if blood loss is suspected?

Hematocrit

17

It takes about ____ years for a vegetarian/ vegan not supplementing with vitamin B12 to develop B12 anemia

20 years