week 12 L1: Skeletal neuromuscular junction Flashcards
Is the skeletal NMJ fast or slow?
fast neural communication
The 5 steps of synaptic transmission of NMJ?
synthesis, storage, release, activation, inactivation
What 2 ways can drugs enhance synaptic transmission?
direct and indirect
Direct stimulation of post synaptic receptors?
a) natural transmitter b) analogues of transmitter
Indirect action via?
a) increased transmitter release
b) inhibition of transmitter removal (stay in synapse)
How can drugs inhibit synaptic transmission? (2)
> blocking synthesis, storage or release from presynaptic neurone.
blocking post-synaptic receptors.
Name the 2 important properties of agonists?
affinity and efficacy
What is efficacy?
ability of agonist, once bound to a receptor, to initiate a biological response.
What is affinity?
Ability to bind to receptor.
Difference between agonist and antagonist?
antagonist has affinity but lack of efficacy
What is a competitive receptor antagonist?
competes with agonist for “agonist binding site”
reversed by increased agonist concentration
depends of conc of agonist and antagonist
What are the 2 regions of ACh?
acetyl moiety
choline moiety
What are ACh neurones called?
Cholinergic
What are the receptors called that ACh acts on?
Cholinoreceptors
Name the 2 types of cholinoreceptors
Nictoninic and Muscarinic
