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Flashcards in Week 2 Deck (30):
1

What stimulates secretion of ADH?

Water defecit

2

What inhibits ADH secretion?

Water excess

3

Symptoms of diabetes insipidus?

Large volume of dilute urine, constant thirst

4

Treatment of diabetes insipidus?

ADH replacement

5

How is amount of Na reabsorption regulated?

By RAAS

6

What is aldosterone secreted in response to?

Rising K or falling Na

7

Where is most of K reabsopred?

In the proximal tubule

8

In the absence of aldosterone where is K reabsorped?

Distal tubule

9

What effect does aldosterone have in K?

Stimulated secretion

10

Where is renin released from?

Granular cells in the JGA

11

3 causes of renin release?

Reduced pressure in afferent arteriole
Reduces NaCl in DT
Increased sympathetic activity of granular cells

12

Where is ANP produced?

In the heart

13

What is the average pH of blood?

7.4

14

What is compensation?

Restoration of pH irrespective of what happens to [HCOs} and PCO2

15

What is correction?

Restoration of pH [HCO3] and PCO2 to normal

16

What is respiratory acidosis?

Retention of CO2

17

3 Causes of respiratory acidosis?

Chronic bronchitis, chronic emphysema, airway restriction

18

What indicates uncompensated respiratory acidosis?

pH <45mmHg

19

What occurs in compensation of respiratory acidosis?

H secretion stimulated
All filtered HCO3 is reabsorbed

20

What is respiratory alkalosis?

Excessive removal of CO2 by the body

21

3 Causes of respiratory alkalosis?

Low inspired PO2 at altitude
Hyperventilation
Hysterical overbreathing

22

What indicates uncompensated respiratory alkalosis?

pH >7.45 and PCO2 <35mmHg

23

What is metabolic acidosis?

Excess H from any source other than CO2

24

3 causes of metabolic acidosis?

Ingestion of acids
Excessive metabolic production of H
Excessive loss of base from the body

25

What indicates uncompensated Metabolic acidosis?

pH <7.35 and [HCO3] is low

26

What occurs in compensation of metabolic acidosis?

Ventilation increases and more Co2 is blown off

27

What is metabolic alkalosis?

Excessive loss of H from the body

28

3 Causes of metabolic alkalosis?

Loss of HCL from stomach (vomiting)
Ingestion of alkali
Aldosterone hypersecretion

29

What indicted uncompensated metabolic alkalosis?

pH 7.45 [HCO3] is high

30

What occurs in the compensation of metabolic alkalosis?

CO2 is retained, HCO3 is excreted