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Flashcards in week 2 Deck (62):
1

amoxicillin class

beta lactam

2

amoxicillin useful against

gram pos, some gram neg

3

amoxicillin binds to

penicillin binding protein 1A

4

what happens when amoxicillin binds to PBP1A?

stops the cross linking of peptidoglycan strands

5

what happens when amoxicillin binds to PBP1A to the bacteria

lysis

6

how do you tackle amoxicillin resistance

give with clavulanic acid which is a beta lactamase inhibitor

7

class of methicillin

beta lactam

8

what does methicillin inhibit

transpeptidase

9

what happens when methicillin bind

stops cross linking of the peptide used in peptidoglycan

10

what is methicillin active against

gram positive

11

what is the peptide in gram pos used to make up the peptidoglycan

D alanyl alanine

12

what is methicillin replaced by in clinic

flucloxacillin and dicloxacillin

13

MRSA

methicillin resistant staph aureus

14

hat does MRSA mean

staph aur resistant to all penicillins

15

what does cefuroxime inhibit

transpeptidase

16

something different about cefuroxime

can cross blood brain barrier

17

who is cefuroxime good against

gram neg and anaerobes

18

benylpenicillin class

beta lactam

19

benylpenicillin binds to

PBPs

20

benylpenicillin also known as

penicillin G

21

extra thing benylpenicillin stops

bacteria autolysin inhibitor

22

benylpenicillin stable against

hydrolytic insult from beta lactamases

23

benylpenicillin is usually against

gram pos

24

in vitro has shown benylpenicillin to be useful against

gram neg and anaeobes

25

oxytetracycline class

30s inhibitor

26

oxytetracycline binds to

ribosome

27

what does the binding of oxytetracycline do

amino acyl tRNA can no longer bind to the A site of the ribocome in the bactera

28

what does oxytetracycline inhibit

translation

29

what is oxytetracycline used for

acne

30

how does oxytetracycline get into the bacteria

it is lipophilic so it can get in/passively diffuse through porin channels

31

who do oxytetracycline work against

broad spectrum

32

erythromycin inhibits?

50s

33

erythromycin class

macrolide

34

erythromycin and pregnancy

can be passed on by breast milk or across the placenta

35

erythromycin active against

actively dividing organisms

36

gentamycin toxic to

ear and kidney

37

gentamycin class

aminoglycoside

38

what can you use for TB

gentamycin

39

broad spectrum RNA polymerase inhibitor

rifampocin

40

rifampocin metabolised by

liver

41

rifampocin treats

mycobacterial infections

42

trimethoprim inhibits

dihydrofolate reductase

43

what happens when trimethorpim binds

cant make thymine

44

trimethoprim is used for

UTI
bronchitis

45

what inhibits dihydofolate synthase

sulfamethoxazole

46

what is sulfamethoxazole

PABA analogue

47

what is PABA

para aminobenxzoic acid

48

what do both trimethorpim and sulfamethoxxazole inhibit

tetrahydrofolate acid

49

what does sulfamethoxazole treat

UTI, bronchitis and prostitis

50

antibacterial drug of last resort

vacomycin

51

vancomycin useful against

gram positive

52

MOA of vancomycin

inhibits encorporation of NAG and NAM into peptidoglycan of gram positive

53

other actions of vancomycin

membrane permeability
RNA synthesis

54

colistin is used for

chronic gram neg infections

55

colistin history

stopped being used but now its back ue to resistance

56

colistin MOA

changes the permeability of cell wall and affet=cts the ribosomes

57

colistin type

polymyxin antibiotic
phosopholipid detergent

58

ciprofloxacin spec

broad

59

ciprofloxacin class

quinolone

60

ciprofloxacin MOA

inhibits DNA gyrase

61

DNA gyrase other name

topoisomerase

62

eye drops and cream

fusidic acid