Flashcards in Week 2: Factors Affecting Wound Healing (Ch 3) Deck (30):
What is an acute wound?
a wound induced by surgery or trauma in an otherwise healthy individual (progresses through normal phases of wound healing in predictable time and manner)
What is a chronic wound?
a wound whose progression through healing phases if prolonged or arrested due to underlying conditions
What does "recalcitrant" mean?
not obedient or not compliant
What are deterrents to expedient wound healing?
1. wound characteristics
2. local factors
3. systemic factors
4. inappropriate wound management
What are characteristics that affect rate of wound management?
MOI, time since onset, wound location, wound dimensions, temperature, wound hydration, necrotic tissue or foreign bodies, infection
What is the ideal wound healing temperature?
37-38 C, 98.6-100.4 F (foam is best)
What is the clinical word for a dry wound?
What is the ideal amount of wound hydration?
moist (too dry impedes current, too wet causes maceration)
What do foreign bodies do?
What does necrotic tissue do?
what is a normal level of microflora for cultures?
What is concerning
10^3 microbes per g/tissue
>10^5 = infection
What are the signs and symptoms of infection?
similar to inflammation, but disproportionate to the wound
What are the key differences for chronic wound healing?
senescent cells, increased number of inflammatory mediators, reduced number of tissue inhibitors of MMPs, reduced or arrested epithelialization, greater bioburden
What are some local factors that affect wound healing?
circulation, sensation, mechanical stress
What are some systemic factors that affect wound healing?
age, nutrition, comorbidities, medication, behavioral risk taking (alcohol, smoking)
Tissue perfusion occurs at what level?
What is sympathetic response?
Older adults have a _______ immune response.
Older adults have a _______ collagen synthesis and strength.
Older adults have epidermal and dermal _______.
Older adults have a _______ number of sweat and oil glands.
Older adults have a _______ pain perception.
Older adults have a _______ inflammatory response.
Older adults have a _______ number of comorbidities.
Older adults have a _______ susceptibility of infection.
What happens to individuals with inadequate nutrition?
increased incidence of complications, delayed healing time
Which medications mainly affect wound healing?
steroids at doses of >30-40 mg/day, chemotherapy, and NSAIDs
How does alcohol abuse affect wound healing?
malnutrition, greater risk for injury, less likely to obtain medical assistance
How does smoking affect wound healing?
decreases tissue perfusion, reduces oxygenation, delays normal cellular response