Week 6: ADH & Diuretics Flashcards Preview

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Flashcards in Week 6: ADH & Diuretics Deck (14):
1

Where do CA inhibitors act? What's an example?

Proximal tubule. Acetazolamide.

2

Where do loop diuretics act?

ascending limb of loop of Henle inhibiting NaKCC transporter

3

Where do thiazide diuretics act?

distal convoluted tubule NaCl symporter

4

Where do potassium sparing diuretics act?

Collecting tubule: inhibit aldosterone receptors or block Na exchange for K and H.

5

Where does ADH work?

Medullary collecting duct -> recruits aquaporins

6

Where do osmotic diuretics work?

proximal tubule and descending limb of loop of Henle

7

2 major loop diuretics

Furosemide & Bumetanide

8

Loop diuretic effect on Na Cl and K

Inc excretion of NaCl, some K+ from collecting tubule exchanged with the excess Na -> depletion of K

9

3 Thiazide diuretics

HCTZ, chlorthalidone, metalazone

10

How do thiazide diuretics contribute to hyperglycemia?

Bind sulfonyl urea receptor on K+ channel -> opens -> hyperpolarizes beta cell -> dec insulin release

11

Why do thiazides and ACEI have good synergy?

Thiazides -> dec Na, dec BP, which stimulate RAS. ACEI blocks RAS effects.

12

What medications are used to treat gout? How do they work?

Allopurinol: inhibits xanthine oxidase. Probenicid or Sulfinpyrazone: inhibit renal organic acid transporters -> excretion of urate.

13

Why should you use NSAIDs not ASA for inflammation in gout?

Salicylates use same transporter -> dec excretion of urate.

14

What diuretic increases blood urate levels?

Thiazides.