Week 6: thrombolytics, anticoagulants and anti-platelet drugs Flashcards Preview

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Flashcards in Week 6: thrombolytics, anticoagulants and anti-platelet drugs Deck (31):
1

What are the 4 categories of antiplatelet drugs?

COX inhibitor, ADP receptor agonist, GPIIb/IIIb receptor inhibitors, adenosine reuptake inhibitor

2

What is the example of COX inhibitor?

Aspirin

3

What are the examples of ADP receptor antagonists?

clopidogrel, ticlopidine, prasugrel

4

What drugs are GPIIb/IIIa receptor inhibitors?

abciximab, eptifibatide, tirofiban

5

What are the adenosine reuptake inhibitor?

Dipyridamole

6

What are the 4 categories of anticoagulants?

indirect thrombin inhibitors, direct thrombin inhibitors, Vit K analogue, factor Xa inhibitor

7

What drugs are indirect thrombin inhibitors?

heparin, LMW heparin, fondaparinux

8

What drugs are direct thrombin inhibitors?

bivalirudin, argatroban, dabigatran, etexilate

9

What is the vitamin K analogue?

warfarin

10

What drug is factor Xa inhibitor?

Rivaroxaban

11

Name tissue plasminogen activators

alteplase, reteplase, tenecteplase

12

What are adverse effects of ADP receptor antagonists? (clopidogrel, ticlopidine, prasugrel)

Bleeding, thrombotic thrombocytopenic purpura

13

What ADP receptor antagonists have the least side effects?

clopidogrel and Prasugrel

14

Does clopidogrel require activation via CYP2C19?

Yes

15

What are adverse side effects of GPIIb/IIIa receptor inhibitors? (abciximab, eptifibatide, tirofiban)

bleeding, thrombocytopenia from chronic use

16

What class is dipyridamole?

adenosine reuptake inhibitor

17

What drugs is dipyridamole treated with?

aspirin or warfarin

18

Which drugs are indirect thrombin inhibitors?

Heparin, LMW heparin, fondaparinux

19

What is the MOA of indirect thrombin inhibitors?

bind to antithrombin to activate, which binds and inhibits thrombin and Xa

20

Is LMW heparin or heavy heparin better at inhibiting Xa?

LMWH

21

What drug is used to reverse heparin?

Protamine

22

What is the mechanism of bivalirudin and argatroban (direct thrombin inhibitors?

bind directly to and inhibit thrombin

23

What is MOA of warfarin?

blocks synthesis of vitamin K dependent clotting factors (2, 7 9 and 10) by inhibiting VKORC1

24

What are AE of warfarin?

bleeding, drug interactions

25

What enantiomer of warfarin is more active?

S enantiomer

26

What physiological processes affect warfarin dosing?

polymorphisms in VKORC1 and CYP2C9

27

How do you reverse too much warfarin?

IV Vitamin K, prothrombin complex concentrates, or recombinant factor VIIa

28

what is the ending of all fibrinolytic drugs?

"plase"

29

What is MOA of fibrinolytic drugs? Alteplase, reteplase, tecteplase?

preferentially activate plasminogen that is bound to fibrin which confines it to the thrombus rather than systemic activation

30

AE of fibrinolytic drugs? (Alteplase, reteplase, tecteplase)

Bleeding

31

What is the antidote for tPA drugs?

aminocaproic acid