Flashcards in Week 6: thrombolytics, anticoagulants and anti-platelet drugs Deck (31):
What are the 4 categories of antiplatelet drugs?
COX inhibitor, ADP receptor agonist, GPIIb/IIIb receptor inhibitors, adenosine reuptake inhibitor
What is the example of COX inhibitor?
What are the examples of ADP receptor antagonists?
clopidogrel, ticlopidine, prasugrel
What drugs are GPIIb/IIIa receptor inhibitors?
abciximab, eptifibatide, tirofiban
What are the adenosine reuptake inhibitor?
What are the 4 categories of anticoagulants?
indirect thrombin inhibitors, direct thrombin inhibitors, Vit K analogue, factor Xa inhibitor
What drugs are indirect thrombin inhibitors?
heparin, LMW heparin, fondaparinux
What drugs are direct thrombin inhibitors?
bivalirudin, argatroban, dabigatran, etexilate
What is the vitamin K analogue?
What drug is factor Xa inhibitor?
Name tissue plasminogen activators
alteplase, reteplase, tenecteplase
What are adverse effects of ADP receptor antagonists? (clopidogrel, ticlopidine, prasugrel)
Bleeding, thrombotic thrombocytopenic purpura
What ADP receptor antagonists have the least side effects?
clopidogrel and Prasugrel
Does clopidogrel require activation via CYP2C19?
What are adverse side effects of GPIIb/IIIa receptor inhibitors? (abciximab, eptifibatide, tirofiban)
bleeding, thrombocytopenia from chronic use
What class is dipyridamole?
adenosine reuptake inhibitor
What drugs is dipyridamole treated with?
aspirin or warfarin
Which drugs are indirect thrombin inhibitors?
Heparin, LMW heparin, fondaparinux
What is the MOA of indirect thrombin inhibitors?
bind to antithrombin to activate, which binds and inhibits thrombin and Xa
Is LMW heparin or heavy heparin better at inhibiting Xa?
What drug is used to reverse heparin?
What is the mechanism of bivalirudin and argatroban (direct thrombin inhibitors?
bind directly to and inhibit thrombin
What is MOA of warfarin?
blocks synthesis of vitamin K dependent clotting factors (2, 7 9 and 10) by inhibiting VKORC1
What are AE of warfarin?
bleeding, drug interactions
What enantiomer of warfarin is more active?
What physiological processes affect warfarin dosing?
polymorphisms in VKORC1 and CYP2C9
How do you reverse too much warfarin?
IV Vitamin K, prothrombin complex concentrates, or recombinant factor VIIa
what is the ending of all fibrinolytic drugs?
What is MOA of fibrinolytic drugs? Alteplase, reteplase, tecteplase?
preferentially activate plasminogen that is bound to fibrin which confines it to the thrombus rather than systemic activation
AE of fibrinolytic drugs? (Alteplase, reteplase, tecteplase)