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Flashcards in White Blood Cell Disorders Deck (17):
1

Infectious associations of Burkitt Lymphoma?

EBV, HIV

2

What grade is Burkitt Lymphoma

high grade

3

List the three small B-cell NHL.

Follicular lymphoma
Mantle cell lymphoma
Marginal zone lymphoma

4

Burkitt lymphoma is what size B cells?

intermediate

5

What is the translocation commonly associated with Burkitt lymphoma? Which genes are affected?

t(8;14)
MYC and heavy chain

6

what is the significance of Ki-67?

indicates a cell's mitotic rate (>95% indicates extreme where almost all the cells are actively dividing, such as in a high grade lymphoma)

7

Classical Hodgkin lymphoma is characterized by _____ cells and what cell markers?

Reed-Sternberg (owl-eye nuclei)
CD15+
CD30+

8

Translocation associated with follicular NHL? Which genes are affected?

t(14;18)
Bcl-2 and heavy chain

9

Translocation associated with mantle cell lymphoma? Which genes are affected?

t(11;14)
cyclin D1 and heavy chain
promotes G1 --> S

10

Translocation associated with acute promyelocytic leukemia? Which genes affected?

t(15;17)
retinoic acid receptor translocated to chromosome 15; RAR disruption blocks maturation and promyelocytes accumulate

11

Chronic Myeloid Leukemia is characterized by increased ___ (cell type) and driven by what mutation?

First line treatment is ___.

matured myeloid cells, especially granulocytes and their precursors. basophils characteristically increased

t(9;22)

Imatinib, which blocks tyrosine kianse activity

12

Polycythemia Vera is a neoplastic proliferation of ____. Associated symptoms include ___ and pts are treated with ___ and ___.

mature myeloid cells, esp RBC.

blurry vision and headache, increased risk of venous thrombosis; flushed face; itching

phlebotomy & hydroxyurea

13

How is Polycythemia Vera distinguished from reactive polycythemia?

PV has low/normal EPO while reactive has high EPO

14

Essential Thrombocythemia is a proliferation of ___.

platelets

15

In what two disorders is CD5 abnormally expressed?

CLL
Mantle zone NHL

16

Which leukemia characteristically infiltrates the gums?

Acute monocytic leukemia

17

CML is characterized by an increase in ___?

mature granulocytes