Flashcards in White Blood Cell Disorders Deck (17):
Infectious associations of Burkitt Lymphoma?
What grade is Burkitt Lymphoma
List the three small B-cell NHL.
Mantle cell lymphoma
Marginal zone lymphoma
Burkitt lymphoma is what size B cells?
What is the translocation commonly associated with Burkitt lymphoma? Which genes are affected?
MYC and heavy chain
what is the significance of Ki-67?
indicates a cell's mitotic rate (>95% indicates extreme where almost all the cells are actively dividing, such as in a high grade lymphoma)
Classical Hodgkin lymphoma is characterized by _____ cells and what cell markers?
Reed-Sternberg (owl-eye nuclei)
Translocation associated with follicular NHL? Which genes are affected?
Bcl-2 and heavy chain
Translocation associated with mantle cell lymphoma? Which genes are affected?
cyclin D1 and heavy chain
promotes G1 --> S
Translocation associated with acute promyelocytic leukemia? Which genes affected?
retinoic acid receptor translocated to chromosome 15; RAR disruption blocks maturation and promyelocytes accumulate
Chronic Myeloid Leukemia is characterized by increased ___ (cell type) and driven by what mutation?
First line treatment is ___.
matured myeloid cells, especially granulocytes and their precursors. basophils characteristically increased
Imatinib, which blocks tyrosine kianse activity
Polycythemia Vera is a neoplastic proliferation of ____. Associated symptoms include ___ and pts are treated with ___ and ___.
mature myeloid cells, esp RBC.
blurry vision and headache, increased risk of venous thrombosis; flushed face; itching
phlebotomy & hydroxyurea
How is Polycythemia Vera distinguished from reactive polycythemia?
PV has low/normal EPO while reactive has high EPO
Essential Thrombocythemia is a proliferation of ___.
In what two disorders is CD5 abnormally expressed?
Mantle zone NHL
Which leukemia characteristically infiltrates the gums?
Acute monocytic leukemia