Wk 3 Pyelonephritis Flashcards

(31 cards)

1
Q

What is pyelonephritis?

A

A type of urinary tract infection (UTI) that generally begins in your urethra or bladder and travels to one or both of your kidneys

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2
Q

What is an UTI protective factor concerning pH?

A

Acidic

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3
Q

Presence of __ is a UTI protective factor

A

Urea

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4
Q

What type of secretions are protective factors against UTIs for men?

A

Prostatic secretions

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5
Q

What type of secretions are protective factors against UTIs for women?

A

Urethral gland secretions

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6
Q

Why are women at higher risk for UTIs compared to men?

A

Urethra is shorter, smaller and in closer proximity to the anus
Higher risk for perineal irritation
Pregnancy/sexual activity

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7
Q

Urine flow is __-directional

A

Uni-directional

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8
Q

As age increases…

A

the risk for UTI increases

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9
Q

Up to 50% of nursing home residents have __

A

bacteriuria

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10
Q

How do condoms increase the risk of getting a UTI?

A

Spermicide is irritating to the vagina

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11
Q

5 risk factors for a UTI

A
Urinary stasis
Immobility
Incontinence
Altered LOC
Bad personal hygiene
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12
Q

Pathogenesis of a UTI is an __ pattern

A

ascending

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13
Q

In what order does a UTI develop?

A
Contaminated perineum 
Urethra
Bladder
Ureter
Kidneys
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14
Q

What is the major risk factor for an upper UTI (pyelonephritis)?

A

Pregnancy

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15
Q

What is the etiology of pyelonephritis? (2 things)

A

Ascending infection, typically with E. coli

Bloodstream infection

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16
Q

Why is pyelonephritis a problem?

A

Can lead to tissue damage, and down the road kidney failure

17
Q

What are symptoms of pyelonephritis? (6)

A
Fever
Chills
Costovertebral angle tenderness
Dysuria
Nausea/Vomiting
Anorexia
18
Q

What is urosepsis?

A

Severe systemic response to pyelonephritis

19
Q

Who is at high risk for urosepsis? (3)

A

Elderly patients
Diabetics
Immunocompromised patients

20
Q

Urosepsis has a high…

A

mortality rate

21
Q

Someone who has recurrent UTIs may receive conventional therapy which is __-__ days

22
Q

A patient with an upper UTI is typically…

A

Admitted to the hospital to receive IV antibiotic therapy

23
Q

What is first line treatment for a UTI?

24
Q

What two drug make up bactrim?

A

sulfamethoxazole and trimethoprim

25
What is the major adverse side effect of bactrim?
anaphylaxis, otherwise well tolerated
26
What is another first-line antibiotic used to treat UTIs
Cirpofloxacin, works locally
27
What is the MOA of ciprofloxacin?
inhibits DNA replication by inhibiting bacterial DNA topoisomerase and DNA-gyrase.
28
What class is ciprofloxacin part of?
fluoroquinolone
29
What is the adverse effects of ciprofloxacin?
GI upset
30
What is the black box warning for ciprofloxacin?
tendinitis and tendon rupture
31
What drug is used for more complex cases of UTIs?
Vancomycin