Wk3 Pancreas, Gall Bladder, Liver Physiology Flashcards Preview

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Flashcards in Wk3 Pancreas, Gall Bladder, Liver Physiology Deck (27)
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1
Q

I cells

location:

respond to?

release?

A

duodenum

release CCK in response to fat and amino acids

2
Q

S cells

location:

respond to?

release?

A

duodenum

respond to H+

release SECRETIN

3
Q

What does secretin do?

A

causes pancreatic ductal cells to release bicarb

4
Q

Neuro activation of pancreatic acinar cells?

A

vagus –> Ach –> M3 receptors

5
Q

look at slide 10

A

Monitor peptide

6
Q

Master regulator of duodenal cluster unit:

A

CCK

7
Q

CCK –> gallbladder?

A

contraction

8
Q

CCK –> Pancreas?

A

Acinar secretion

9
Q

CCK –> stomach?

A

reduced emptying

10
Q

CCK –> sphincter of Oddi?

A

relaxation

11
Q

CCK –> brain?

A

decreased hunger/food intake

12
Q

Brush border enzyme that activates trypsinogen?

A

enteropeptidase

13
Q

Where do pancreatic duct cells get bicarb? (2 places)

A

blood (from alkali tide of stomach) –> Na+/2HCO3- symporter

intracellular CA

14
Q

Hoe does bicarb get from duct cell into lumen?

A

Cl-/bicarb exchangers

15
Q

How does Cl- get into lumen for exchange with bicarb?

A

CFTR

**activated by secretin

**this is why CF patients have decreased bicarb secretion

16
Q

3 causes of pancreatitis:

A
  1. CF
  2. Occlusion fo pancreatic duct (gallstones, malignancy)
  3. EtOH –> hyperstimulation of acinar cells –> intracellular trypsin activation –> cell death
17
Q

Regulator of nutrient assimilation:

A

hypothalamus

18
Q

GLP-1 general role:

A

increase insulin

decrease glucagon

**direct- pancreas

**indirect- hypothalamus

19
Q

GLP-1 cell of origin:

A

intestinal L cells

20
Q

GIP role and cell of origin:

A

K cells –> pancreatic beta and alpha cells –> increased insulin, decreased glucagon

21
Q

Two negative regulators of pancreatic beta cell secretion of insulin:

A

somatostatin

NE

22
Q

4 satiety signal acting on hypothalamus:

A
  1. GLP1
  2. CCK
  3. Insulin
  4. Leptin (adipose tissue)
23
Q

hormone produced in fundus of stomach (and hypothalamus) during fasting to stimulate appetite:

A

grehlin

24
Q

great summary chart on

A

slide 22

25
Q

hardening of liver due to irreversible deposition of excess collagen:

A

cirrhosis

26
Q

Pathology of cirrhosis:

A

oxidative stress (infx, EtOH) –> Kupffer cells release cytokines –> induce collagen production by stellate cells

27
Q

Bile review

A

slide 30 –> end of ppt