Flashcards in Wk3 Small intestine/Colon pt1 Deck (41):
List complications of Meckel's diverticulum
1. ulceration dt ectopic gastric mucosa
4. fistula w/bladder
List four kinds of diarrhea:
1. Secretory -- isotonic stools
2. Osmotic -- lactase deficiency
3. Malabsorptive -- steatorrhea
4. Exudative -- inflammatory, neutrophils, bloody stool
How is Whipple disease diagnosed?
-PCR on tissue biopsy
Most common (80%) cause of intestinal obstruction:
loss of normal propulsive function of bowel in absence of mechanical obstruction:
Defect in the wall of peritoneal cavity:
fibrous band of scar tissue between bowel segments:
Twisting of bowel loop around its mesenteric base:
Segment of bowel telescopes into immediate distal segment of bowel:
Common cause of intussusception in infants?
Common cause of intussusception in older children and adults?
intraluminal tumor or mass
Rule of 2's?
Failed involution of which structure causes Meckel's diverticulum?
premature arrest of neural crest cell migration
premature death of ganglion cells
Most common location of Hirschsprung's disease:
distal sigmoid colon and rectum
Two nerve plexuses affected by Hirschsprung's:
Pathophys of Hirschsprung's disease:
absent peristaltic contractions and proximal dialation
diffuse mucosal involvement
reduced absorptive surface (ie. Celiac)
Partial or segmental malabsorption?
interference with absorption of specific nutrients
ie. vit B12
3 common causes of malabsorption in the USA?
1. chronic pancreatitis
2. celiac disease
Clinical definition of diarrhea:
greater than 3 loose stools per day
less than 14 days
greater than 4 weeks
intraepithilial lymphocytes with vilious atrophy
alleles associated with Celiac:
Immune cells responsible for reaction in Celiac:
Gluten by product that becomes antigen on APC's in celiac:
enzyme that converts gliadin to deamidated gliadin:
Ab's that may be dx for celiac?
Histologic appearance of Celiac:
Tropical sprue cause?
Tx: broad spec abx
Location for Tropical sprue:
Common deficiency in Tropical sprue?
mutation of MTP?
Pathophys of abetalipoproteinemia?
Enterocyte can't package TGs into chylomicrons
TG's accumulate in cells
(lipid membrane defects)
Pathophys of Whipple disease?
Organisms accumulate in Mac's --> clog up lamina propria --> lymphatic obstruction --> chylomicrons can't get to blood
can affect other organs:
right heart valves
Definitive dx for Whipple disease:
PCR on tissue biopsy