Wound healing

Question 1

Systemic factors affecting wound healing

Answer 1

1. Age of patient, gender
2. Circulatory status
3. Nutrition
   
   • zinc, vitamin Cetc are essential in wound healing
4. Metabolic status
   
   • Patients with DM and hypothyroidism have poor would healing
5. Hormones
6. Medication (Glucocorticoid steroids, NSAIDs, chemotherapy)

Question 2

Process of scar formation

Answer 2

hemostasis and inflammation → granulation tissue (vascular connective tissue composed of vascular capillaries, fibroblasts/myofibroblasts and a mixture of inflammatory cells) → collagen synthesis and deposition (leading to wound contraction) →remodelling→ scar formation

Question 3

granulation tissue formation

Answer 3

1. angiogenesis (new blood vessel development from existing vessels)
2. migration and proliferation of fibroblasts into site of injury

Question 4

angiogenesis

Answer 4

1. migration of endothelial cells towards area of tissue injury
2. endothelial cells divide to form solid sprouts
3. sprouts develop a lumen by fusion of intracytoplasmic vacuoles containing RBCs
4. formation of blood vessels (capillaries)
5. vessels (capillaries) join to form an arborizing vascular network