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Pharmacology > X - Hematologic Agents > Flashcards

X - Hematologic Agents Flashcards

1
Q

Iron Deficiency Anemia

A

Ferrous Sulfate (Fumarate - ↑ elemental Fe)

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2
Q

Megaloblastic anemia, vitamin B12 deficiency

A

Cyanocobalamin

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3
Q

Megaloblastic anemia, prevention of neural tube defects (spina bifida)

A

Folic Acid

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4
Q

Anemia in CKD

A

EPO

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5
Q

Neutropenia, agranulocytosis

A

Filgrastim

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6
Q

Chemotherapy-induced thrombocytopenia

A

Oprelvekin

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7
Q

Acute treatment of DVT, PE and AMI, PTT monitoring, SE: bleeding, thrombocytopenia

A

Heparin

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8
Q

Low molecular weight heparin, less risk for thrombocytopenia, does not need monitoring

A

Enoxaparin

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9
Q

Treatment of heparin-induced thrombocytopenia

A

Lepirudin

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10
Q

Antidote to heparin-induced bleeding

A

Protamine Sulfate

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11
Q

Chronic anti-coagulation, SE: bleeding, skin necrosis, many drug interactions

A

Warfarin

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12
Q

Antidote to warfarin (immediate reversal)

A

Fresh Frozen Plasma (FFP)

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13
Q

Antidote to warfarin (slow reversal)

A

Vitamin K

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14
Q

Test for intrinsic pathway function

A

PTT

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15
Q

Test for extrinsic pathway function

A

PT

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16
Q

Why is an overlap between heparin and warfarin done?

A

warfarin’s effect requires elimination of preformed clotting factors (8-60h), bypass initial prothrombotic effect of warfarin (skin necrosis)

17
Q

Thrombolysis in AMI, ischemic CVD and PE, SE: bleeding

A

Alteplase (rtPA)

18
Q

Bacteria-derived thrombolytic, decreased effect on subsequent uses due to antibody formation

A

Streptokinase

19
Q

Antidote to thrombolytic overdose

A

Aminocaproic/Tranexamic Acid

20
Q

Irreversible COX inhibitor, instant prevention of arterial thrombosis, SE: tinnitus, hypersensitivity, Reye syndrome, Samter triad (asthma, NSAID sensitivity, and nasal/ethmoidal polyposis)

A

Aspirin

21
Q

ADP inhibitor, additive effects with aspirin

A

Clopidogrel

22
Q

Glycoprotein IIb-IIIa inhibitor

A

Abciximab

23
Q

Phosphodiesterase inhibitor, cardiac stress testing

A

Dipyridamole

24
Q

Toxic Dose of Aspirin

A

150 mg/kg

25
Q

Lethal Dose of Aspirin

A

500 mg/kg

26
Q

Aspirin Hypersensitivity

A

Samter Triad (asthma, NSAID sensitivity, and nasal/ethmoidal polyposis)

27
Q

Aspirin Toxicity

A

Coma, Hyperventilation, Acidosis (HAGMA), Fever, Seizure

28
Q

Acid-base abnormality in salicylate poisoning

A

respiratory alkalosis with HAGMA

29
Q

Aspirin Intoxication: Adults

A

mixed acid-base disorder (respiratory alkalosis with HAGMA)

30
Q

Aspirin Intoxication: Children

A

pure acid-base disorder

31
Q

Completely halt the ETC

A

ETC Inhibitors

32
Q

Dissipate proton gradient without interrupting ETC

A

Uncouplers

Pharmacology (34 decks)

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