02.07 Metabolic Syndrome and Coronary Artery Disease Flashcards Preview

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Flashcards in 02.07 Metabolic Syndrome and Coronary Artery Disease Deck (26):
1

Regulate inflammatory response, lipoprotein metabolism, vascular inflammation

Adipokines

2

Entero-protective
Insulin-sensitizing, anti-inflammatory, lipid regulatory atheroprotective

Adinopectin

3

Produced by fat cells
Satiety hormone

Leptin

4

Inc in monocyte and vascular NF kappa beta and ERK 1-dependent inflammatory responses

Resistin

5

State of chronic low-grade inflammation with the profound system effects

Metabolic syndrome

6

Primary therapy for metabolic syndrome

Lifestyle changes

7

Estimates the risk of coronary heart disease

Framingham risk score

8

Primary prevention of metabolic syndrome

Assess traditional atherosclerotic cardiovascular disease risk factors every 4-6 years in adults 20-79 years of age who are free from ASCVD and estimate 10-year ASCVD risk
Dietary patterns

9

Secondary prevention of metabolic syndrome

Intensive risk-reduction therapies for patients with established coronary and other atherosclerotic vascular disease
Dietary patterns and exercise

10

Management for triglyceride levels 150-199 mg/dL

Institute weight reduction and increase physical activity
Carbohydrate-controlled dieting

11

Management for triglyceride levels 200-499 mg/dL

Reduce non-HDL cholesterol
Statins, fibrates and nicotinic acid

12

Diabetes prevention

Weight reduction of 5-10%
Sodium intake of <1.5 - 2.4
Metformin

13

Low glycemic index food
Complex unrefined carbohydrates
Viscous soluble fibers
Protein intake of 10-35% of total calorie intake
25%-35% of calories from fat

DASH diet

14

High consumption of fruits, vegetables legumes, and grains, moderate alcohol intake, a moderate-to-low consumption of dairy and meat products and a high monounsaturated to saturated fat ratio

Mediterranean diet

15

Recommendation for lower risk (LDL < 160 mg/dL)

Lifestyle modifications
Pharmacologic intervention if Ldl-C >/= 190 after lifestyle modification

16

Recommendation for moderate risk (LDL < 130 mg/dl)

Lifestyle modifications
Pharma intervention if LDL-C >/= 160 mg/dL

17

Recommendation for moderately high risk (LDL < 130 mg/dL)

Lifestyle modification
Pharma therapy if LDL-C >/= 130 or optionally if >/= 100 after LM

18

Recommendation for high risk (<100 mg/dL)

LM
Pharma if LDL-C >/= 100 or optionally >/= 70

19

Recommended saturated fat level

Less than 7%

20

Recommended cholesterol intake

Less than 200 mg a day

21

Recommended fiber intake

10-25 g/day

22

Recommended stanols or sterols level

2 grams per day

23

Omega 3 fatty acid found mainly in fatty fish and some commercially made sources from algae

Docosahexanoic acid

24

Omega 3 fatty acid found mainly in fatty fish

Eicosapentaneoic acid

25

Omega 3 fatty acid found in plant sources like flax, canola and soy

Alpha-linolenic acid

26

Recommendation for omega 3 intake

General population: just eat fish
CAD: 1 g/day
Hypertriglyceridemia/HTN: 1-4 g/day