044 Pain

Question 1

What are the 3 dimensions of pain

Answer 1

Sensory dimension - location, intensity, threshold
Primary affective dimension - fear, distress
Secondary affective dimension - anxiety, depression fatigue

Question 2

What is the main drug used for neuropathic pain?

Answer 2

Gabapentin

Question 3

What peptides do C fibres contain?

Answer 3

Substance P, CRGP

Question 4

What is TRPV1 (Capsaicin RECEPTOR)?

Answer 4

This is a receptor in the C fibres that is a major component of peripheral sensitisation.

Question 5

Which receptor does the NGF stimulate during pain sensitization?

Answer 5

This activates the TrkA receptor

Question 6

What is the lamina 1 pathway?

Answer 6

1.It originates from lamina 1, mainly NK1 receptor.
2. Terminates in the parabrachial nucleus
3. Connect to amygdala and hypothalamus
Pain perception.

Question 7

What is substance P-saporin treatment?

Answer 7

Substance P saporin targets the NK1 receptor to diminish neuropathic pain ascending pathways. It has no effect on acute pain processing but later developing pain sensitivity is lost for chronic pain.

Question 8

What are saporin demorphin conjugates used for?

Answer 8

Ablation of the rostral ventral medulla, causing inability for pain modulation descending tract. This prevents chronic pain.

Question 9

What is the Gate Control Theory of pain?

Answer 9

You can stimulate Abeta fibres with tactile, non-noxious stimuli, which causes inhibitory interneurons in the dorsal horn that inhibits pain c fibres.