Alcoholic liver disease Flashcards

1
Q

Define

A

Chronic liver disease caused by excess of alcohol

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2
Q

Presentation

A

Fatty liver-usually no symptoms
Possible hepatomegaly on examinations- enlarged
Alcoholic hep- rapid onset jaundice
Nausea
Anorexia
Fever
May be asymptomatic with complications of cirrhosis

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3
Q

Most chronic liver disease in western world

A

Alcoholic liver disease

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4
Q

Cause

A

Excessive consumption of alcohol
Exact mechanism unknown
Beyond identifying alcohol as a hepatoxin
Some genetic deposition

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5
Q

Investigation

A

Liver bio Chem- AST ALT rise

Bloods - elevated MCV

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6
Q

Treatement

A

Lifelong abstinence of alcohol

Corticosteroids to control inflammation if no renal failure

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7
Q

Complications

A

Liver failure if untreated

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8
Q

Pathology

A

Fatty liver: biopsy finding
Hepatocytes contain macrovesicular droplets of triglycerides
Fat disappears on cessation of alcohol intake
But otherwise progresses
To cirrhosis and fibrosis
As result of mitochondrial damage
Alcoholic hep: ballooned hepatocytes
Contain eosinophilia material
Call Mallory bodies
Surrounded by neutrophils
Fibrosis and foamy degeneration of hepatocytes
Usually coexists with cirrhosis
Final stage of alcholic liver disease is:
Distraction of liver architecture and fibrosis
Regenerating nodules
Bring micro nodular cirrhosis
Mallory bodies also present

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