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msk 2 > Pharmacology - Pain Management and Treatment of MSK Disorders > Flashcards

Pharmacology - Pain Management and Treatment of MSK Disorders Flashcards

1
Q

most side effects of NSAIDs occur via inhibition of which enzyme

a.cox1
b.cox2
c.cox3

A

a.cox1

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2
Q

most anti inflammatory effects of NSAIDS occur via inhibition of which enzyme

a.cox1
b.cox2
c.cox3

A

b.cox2

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3
Q

which NSAID is used in pain and inflammation in MSK disease, post operatively and in dental pain

a.aspirin
b.paracetemol
c.ibruprofen
d.advil
e.diclofenac

A

c.ibruprofen

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4
Q

which NSAIDis is used for pain and inflammation in MSK disease, acute gout and post pain

a.aspirin
b.paracetemol
c.ibruprofen
d.advil
e.diclofenac

A

e.diclofenac

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5
Q

why should individuals over 60 not take primary preventative aspirin

A

risk of life threatening GI bleed

but over 60s with atherosclerosis should take secondary preventative aspirin

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6
Q

which drugs in combination with NSAIDs cause increased risk of GI bleeding

a.anticoagulants and antidepressants

b.ACEi/ARBs

c.diuretics

d.methotrexate

A

a.anticoagulants and antidepressants

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7
Q

which drugs do NSAIDS cause reduced efficacy in

a.anticoagulants and antidepressants

b.ACEi/ARBs

c.diuretics

d.methotrexate

A

b.ACEi/ARBs

can also cause kidney failure with ACEi

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8
Q

which drugs do NSAIDs cause reduced efficacy in

a.anticoagulants and antidepressants

b.ACEi/ARBs

c.diuretics

d.methotrexate

A

c.diuretics

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9
Q

which drugs in combination with NSAIDs cause increased toxicity especially if the other drug is used in cancer

a.anticoagulants and antidepressants

b.ACEi/ARBs

c.diuretics

d.methotrexate

A

d.methotrexate

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10
Q

what NSAID is appropriate for use in children

A

paracetamol and brufen

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11
Q

hypersensitivity reaction leading to erythema multiforme major

A

Steven johnson syndrome

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12
Q

contraindications of NSAIDs

A

PUD
ASPIRIN reyes syndrome
use with caution in pregnancy , especially 3rd trimester can close ductus arterioles in utero, retail impairment, hypertension, hypersensitivity reaction
anticoagulants contraindicated

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13
Q

corticosteroids used in MSK disease when ..

A

NSAIDs contraindicated
pud, poor renal function

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14
Q

what is used to relieve pain and stiffness in arthiritis

a.low dose prednisolone
b.high dose prednisolone
c.beclomethasone
d.methotrexate

A

a.low dose prednisolone

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15
Q

what is used for severe flare ups in arthiritis

a.low dose prednisolone
b.high dose prednisolone
c.beclomethasone
d.methotrexate

A

b.high dose prednisolone

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16
Q

what effects do steroids have on large doses of opioids

a.reduce the risk associated
b.increase the risk associated

A

reduce risk associated with large doses of opioids

17
Q

DMARDs examples

A

methotrexate leflunomide

18
Q

key points about DMARDs

A

longer onset of action 4-6 weeks
affect underlying cause of disease
care with adverse effects
extreme caution in female patients due teratogenic effects

19
Q

Biological DMARDs should only be considered when

A

after specialist assessment and advice from a rheumatologist

20
Q

True or false DMARDs can be started at the same time as NSAIDs

A

true
good as DMARDs take 4-6 weeks before effects seen

21
Q

what is used as an manager of acute gout attacks

a.methotrexate
b.diclofenac
c.colchine
d.allopurinol

A

c.colchine

22
Q

gout presentation

A

hot red big toe

23
Q

which of these drugs is an inhibitor of microtubules in neutrophils and is used for acute gout attacks

a.colchine
b.allopurinol
c.methotrexate
d.leflunomide
e.denosumab

A

a.colchine

24
Q

which of these drugs is a inhibitor of xanthine oxidase and is used in management of long term gout to decrease uric acid levels

a.colchine
b.allopurinol
c.methotrexate
d.leflunomide
e.denosumab

A

b.allopurinol

25
Q

osteoarthritis symptoms

A

pain
swelling
loss of function

26
Q

pain management for osteoarthritis

A

exercise ans therapy, weight loss , TENS

paracetamol NSAIDS, PPI given with this and opioids

imtraarticular steroid injection eg triamcinolone

msk 2 (16 decks)

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