2022 - Lesson 33 Male Infertility Flashcards
When is sperm DNA fragmentation analysis recommended in male infertility workup?
Sperm DNA fragmentation analysis is used for specific indications such as recurrent pregnancy loss.
What are Selective Estrogen Receptor Modulators (SERMs), and how are they used in male infertility?
SERMs like Clomiphene are recommended for idiopathic oligozoospermia.
What is the stance on antioxidant therapy in the management of male factor infertility?
Evidence supports the use of antioxidant supplements in specific cases, with caution against overuse due to a lack of robust evidence.
What are the considerations for testosterone therapy in male infertility with low testosterone?
Testosterone therapy is considered for patients with low testosterone, weighing the risks and benefits.
What is the guideline’s stance on genetic testing in male infertility workup?
Genetic testing, including sperm DNA fragmentation analysis, chromosomal abnormalities, and Y-chromosome microdeletions, is recommended for specific indications.
What hormonal treatments are suggested for abnormal semen parameters in male infertility?
The guideline recommends testosterone therapy for patients with low testosterone and Selective Estrogen Receptor Modulators (SERMs) like Clomiphene for idiopathic oligozoospermia.
What does the document define as the timing for the initial evaluation of infertility?
: Infertility is defined as the failure to conceive after 1 year of unprotected sexual intercourse, and couples should be evaluated by a fertility specialist at that point.
What does the document recommend for men in couples experiencing recurrent pregnancy loss (RPL)?
The document recommends that men in couples with RPL be evaluated with a karyotype and SDF analysis.
What does the 2020 guideline recommend regarding the initial evaluation of infertility in couples?
The 2020 guideline recommends concurrent assessment of both male and female partners as part of the initial infertility evaluation.
What are the potential consequences of advanced paternal age in relation to fertility and offspring health?
Advanced paternal age can contribute to genetic mutations, chromosomal abnormalities, worsened semen parameters, an increased rate of miscarriage, and greater morbidity in offspring, including associations with certain malignancies and neuropsychiatric conditions.
What is the recommended evaluation timing for couples where the female partner is 35 or older?
The recommendation is for couples to be evaluated after 6 months of failure to conceive if the female partner is 35 or older.
Age-related decline in ovarian reserve and oocyte quality leads to the recommendation for earlier evaluation.
Earlier evaluation is recommended due to age-related decline in ovarian reserve and oocyte quality.
What challenges are associated with women aged 35 or older in terms of fertility?
There is a decline in fertility potential and an increased time to conception in women of this age.
What is new about the 6-month time interval for evaluation in the AUA/ASRM guideline?
The specific time interval of 6 months for evaluation had not been previously explicitly stated in the AUA/ASRM guideline.
What does the 2020 guideline recommend regarding the concurrent assessment of male and female partners?
The 2020 guideline recommends that male and female partners undergo concurrent assessment as part of the initial infertility evaluation, focusing on abnormal semen parameters or concerns for male factor infertility.