1.4 Pharmacology Of The Nervous System Flashcards
What is pharmacology
Study of how chemical agents (drugs) can influence the function of living systems
A chemical substance (drug) that interacts with a specific target within a biological system to produce a physiological effect
How do individual drugs produce their effect? (3)
- Where is the effect produced
- Where is the target for the drug?
- What is the response produced after interaction with this target?
Why do people take Heroin
Euphoria
Analgesia (pain relief)
Cough suppression
Analgesia
Pain relief
Pain relief term
Analgesia
Where is the effect of analgesia
Peri-aqueductal grey region
Where is the effect of euphoria produced
Ventral tegmental area
Where is the effect of cough suppression produced
Solitary nucleus
Target for opioids
Opioid receptors
Drugs target classes
Receptors
Enzymes
Transport proteins
Ion channels
(Proteins)
Drugs can act on targets to…
Enhance or prevent activation (stimulate or block effect being produced)
Is selectivity more important for a drug or an endogenous compound?
Drugs
Endogenous- delivered by neurones what and when needed, localised response
Drugs agents specifically delivered and so could potentially bind to other receptors
Selectivity
Lock and key hypothesis
Need a high degree of selectivity
Side effect
Effect produced by the drug that is secondary to the intended effect
Adverse effect
A side effect with negative health consequences
