Other Major Blood Groups Flashcards

1
Q

Landsteiner-Wiener

A

ISBT 016

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2
Q

LW gene is on

A

Chromosome 19

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3
Q

LW antigen is carried by

A

ICAM-4

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4
Q

To differentiate D antigens from LW, treat cells with

A

Dithiothreitol (DTT)

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5
Q

Lewis

A

ISBT 007

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6
Q

Not intrinsic to RBCs; produced by tissue cells and secreted into body fluids

A

Lewis

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7
Q

Le gene is found on

A

Chromosome 19

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8
Q

Le (a+b+)

A

Asians

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9
Q

lele

A

Blacks

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10
Q

Present only if both Le and Se are present

A

Leb

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11
Q

Associated with H.pylori infection

A

Leb

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12
Q

MNSs

A

ISBT 002

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13
Q

MNSs gene is located on

A

Chromosome 4

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14
Q

Well developed at birth; may cause HDN; demonstrate dosage effect; used in paternity testing

A

MNSs

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15
Q

Abs react more strongly with homozygous RBCs

A

Dosage effect

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16
Q

Found on glycophorin A; differ at amino acids at pos 1&5

A

MN

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17
Q

Found on glycophorin B; differ at amino acids at pos 29

A

Ss

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18
Q

Formed when individual is S+s+

A

U phenotype

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19
Q

Cold reacting; IgG/IgM; rxn enhanced at 6.5 (acidic); seen in multiparous women

A

Anti-M

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20
Q

Cold reacting; IgG/IgM; rxn enhanced at alkaline pH; seen in renal dialysis patients

A

Anti-N

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21
Q

MNSs Ab that is IgG in nature; may cause HDN&HTRs

A

Anti-S & Anti-s

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22
Q

Found in S-s- individuals; may cause HDN&HTRs

A

Anti-U

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23
Q

Receptor for E.coli

A

Glycophorin A

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24
Q

Receptor for P.falciparum

A

Glycophorin A&B

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25
Q

P1Pk

A

ISBT 003

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26
Q

Deteriorates rapidly upon storage; may cause false neg in old specimens; poor expression at birth

A

P1 antigen

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27
Q

Full expression of P1 Ag

A

7 years old

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28
Q

Slightly more common in Japan, North Sweden, and in an Amish group in Ohio

A

P null

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29
Q

Receptor for Parvovirus B19 Ag

A

P antigen

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30
Q

Receptor for Shiga toxin

A

Pk antigen

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31
Q

Receptor for P fimbriated uropathogenic E.coli

A

All P antigens

32
Q

Naturally occurring; IgM; neutralized by hydatid cyst fluid from E. Granulosus; found in patients with fasciolasis

A

Anti-P1

33
Q

IgM/IgG; first described in patient suffering from adenocarcinoma of the stomach; associated with spontaneous abortions in early pregnancy

A

Anti-PP1Pk (Anti-Tja)

34
Q

IgG autoAb; biphasic hemolysin; aka Donath-Landsteiner Ab; produced by patients with Paroxysmal Cold Hemoglobinuria

A

Autoanti-P

35
Q

Associated with Cold Agglutinin Disease & Primary Atypical Pneumonia (Walking Pneumonia caused by Mycoplasma pneumoniae)

A

Anti-I / Pathogenic Autoanti-I

36
Q

Associated with IM, EBV infxn; alcoholic cirrhosis

A

Anti-i

37
Q

Associated with congenital cataracts

A

Adult I

38
Q

Disease associated with individuals that do not convert i to I after 18 months

A

Hereditary Erythroblastic Multinuclearity with Positive Acidified Serum (HEMPAS) test or Chronic Dyserythropoietic Anemia II

39
Q

I blood group

A

ISBT 027

40
Q

Kell

A

ISBT 006

41
Q

KEL gene is found on

A

Chromosome 7

42
Q

IgG; reactive in AHG phase; warm reacting; severe HDN and HTR

A

Anti-K

43
Q

Produce by Ko phenptype; cause HTR&HDN

A

Anti-Ku

44
Q

Result of infection from Steptococcus/Enterococcus faecium

A

Acquired K phenomenon

45
Q

Associated with E.coli 0125 B15 infxn

A

Anti-K

46
Q

Absence of Kx on WBCs

A

Chronic Granulomatous Disease

47
Q

Chracterized by neuroacanthocytosis, cardiomegaly, muscular dystrophy, cardiomyopathy, areflexia, inc. Creatine Phosphokinase and Carbonic Anhydrase III

A

McLeod Syndrome

48
Q

Absence of Kx and Km on RBCs; depressed expression of all Kell antigens; X-linked; acanthocytosis

A

McLeod Phenotype

49
Q

Duffy

A

ISBT 008

50
Q

Fy gene is found on

A

Chromosome 1

51
Q

Made by duffy null individuals

A

Anti-Fy3

52
Q

Resistance to P. Vivax and P.knowlesi infections; seen in Blacks

A

Duffy null

53
Q

Kidd

A

ISBT 009

54
Q

Jk gene is found on

A

Chromosome 18

55
Q

Notorious in blood banks that cause delayed severe and fatal HTR; rarely cause HDN

A

Anti-Jka & Anti-Jkb

56
Q

Drug-induced HTR in patients taking Aldomet or Methyldopa (hypertensive drugs)

A

Anti-Jka & Anti-Jkb

57
Q

Found in Jk (a-b-); severe and immediate and delayed HTRs; mild HDN

A

Anti-Jk3

58
Q

IgM Abs

A

“LIPMAN”

1) Lewis
2) l
3) P1
4) M
5) ABH
6) N

59
Q

IgG Abs

A

1) Rh
2) SsU
3) Duffy (Fy)
4) Kell (K)
5) Kidd (Jk)
6) Lutheran (Lb)

60
Q

MF rxn

A

1) Lutheran
2) Sda

61
Q

Absent in PNH III

A

1) JMH
2) Cromer
3) Cartwright
4) Dombrock

62
Q

Carbohydrate Ag

A

“LIP”

1) Lewis
2) l
3) P

63
Q

Poorly developed at birth

A

Lewis, Lutheran, P1

64
Q

Well developed at birth

A

Duffy, MNSs, Kell, Kidd

65
Q

In-Vitro Hemolysis

A

Anti Lea/Leb, Anti-Tja, Vel

66
Q

Dosage effect

A

Rh, Duffy, MNSs, Kidd, Kell, Lutheran

67
Q

HTLA Abs

A

Chido/Rogers, Kn, JMH, York, Cost, McCoy

68
Q

Decreased Abs in pregnancy (postpartum)

A

Lewis, Sda (dec Ag in pregnancy)

69
Q

Destroyed by enzymes

A

Duffy, MNS, Xga, JMH, Ch/Rg, Pr

70
Q

Enhanced by enzymes

A

“KALIPER”

1) Kidd
2) ABO
3) Lewis
4) I
5) P1
6) Rh

71
Q

Unaffected by enzymes

A

U, Kell, Lutheran, Scianna

72
Q

Destroyed by sulfhydryl agents

A

Kell

73
Q

Anti-P1 is neutralized by

A

Hydatid cyst fluid, turtle dove egg white, pigeon dropping

74
Q

Anti-Le, Anti-H is neutralized by

A

Saliva, Plasma/serum

75
Q

Anti-Ch/Rg is neutralized by

A

Plasma/serum

76
Q

Anti-Sda is neutralized by

A

Guinea pig urine

77
Q

I antigen is neutralized by

A

Mother’s milk