Other Major Blood Groups Flashcards
Landsteiner-Wiener
ISBT 016
LW gene is on
Chromosome 19
LW antigen is carried by
ICAM-4
To differentiate D antigens from LW, treat cells with
Dithiothreitol (DTT)
Lewis
ISBT 007
Not intrinsic to RBCs; produced by tissue cells and secreted into body fluids
Lewis
Le gene is found on
Chromosome 19
Le (a+b+)
Asians
lele
Blacks
Present only if both Le and Se are present
Leb
Associated with H.pylori infection
Leb
MNSs
ISBT 002
MNSs gene is located on
Chromosome 4
Well developed at birth; may cause HDN; demonstrate dosage effect; used in paternity testing
MNSs
Abs react more strongly with homozygous RBCs
Dosage effect
Found on glycophorin A; differ at amino acids at pos 1&5
MN
Found on glycophorin B; differ at amino acids at pos 29
Ss
Formed when individual is S+s+
U phenotype
Cold reacting; IgG/IgM; rxn enhanced at 6.5 (acidic); seen in multiparous women
Anti-M
Cold reacting; IgG/IgM; rxn enhanced at alkaline pH; seen in renal dialysis patients
Anti-N
MNSs Ab that is IgG in nature; may cause HDN&HTRs
Anti-S & Anti-s
Found in S-s- individuals; may cause HDN&HTRs
Anti-U
Receptor for E.coli
Glycophorin A
Receptor for P.falciparum
Glycophorin A&B
P1Pk
ISBT 003
Deteriorates rapidly upon storage; may cause false neg in old specimens; poor expression at birth
P1 antigen
Full expression of P1 Ag
7 years old
Slightly more common in Japan, North Sweden, and in an Amish group in Ohio
P null
Receptor for Parvovirus B19 Ag
P antigen
Receptor for Shiga toxin
Pk antigen