Current management of recurrent pregnancy loss TOG 2022 Flashcards

1
Q

Risk of recurrent pregnancy loss in those 40-44years

A

13%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Risk miscarriage 12-34

A

Similar 11-15%
Lowest 20-24 11%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Miscarriage rates 35-39

A

25%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Miscarriage rates 40-44

A

51%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Miscarriage rates >45

A

93%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which epidemiological factor seem to increase risk of recurrent miscarriage

A

High intensity occupation activity
Fhx
Maternal age
Advanced paternal the
Previous pregnancy loss
BMI >25

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What proportion of recurrent miscarriage have identifiable cause

A

26%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Chromosomal abnormality account for what % early pregnancy loss & 13-20 weeks

A

<13 70%
13-20 20%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

When should heredity thrombophilia testing be offered?

A

2nd trimester loss
RF - Fhx/personal Hx VTE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Genetic techniques available for POC

A

Karyotyping
Limited by:
failure of cell culture (rate of 20%)
maternal cell contamination (MCC) (rate of 22%)
Fluorescence in situ hybridisation (FISH)
In practice, out of the 24 chromosome probes, only the 5–7 commonly involved in aneuploidy are selected.
Array-based comparative genomic hybridisation (aCGH)
avoids the limitations of cell culture failure and MCC
most recommended if genetic analysis of POC is to be performed.
Next generation sequencing (NGS)
currently no evidence to replace any other technique

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Use of progesterone in miscarriage/recurrent miscarriage

A

Hx bleeding & 1+ miscarriage
- 400mg BD until 16 weeks

3+ pregnancy loses
200mg BD, until 12 weeks
If bleeding 400 until 16 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

In chromosomal abnormalites does PGT reduce the rate of pregnancy loss/live birth rate?

A

Reduces pregnancy loss
No impact on live birth rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly