Pharmacology Flashcards
Anticoagulant (Heparin, Enoxaparin, Fondaparinux)
Used in thrombotic disorders
Interactions: All herbal medications, NSAIDS
Therapeutic use: Stroke, Pulmonary embolism (sudden blockage in a lung artery),
Deep vein thrombosis (blood clots that form inside veins)
Complications: Toxicity, Hemorrhage, Neurological damage from hematoma- (collection of blood outside the blood vessels)
Antiplatelet
Aspirin, Abciximab, Clopidogrel, Dipyridamole
Therapeutic Use: Primary prevention of acute myocardial infarction, prevention of ischemic stroke or transient attack
Complications: GI effects (nausea vomiting, dyspepsia), Bleeding
Contraindications/Precautions: Renal and liver disease, older adults, pregnant, bleeding disorders
Thrombolytic Agents
(Alteplase)
Therapeutic Use: Given to dissolve thrombi by stimulating the conversion of plasminogen to plasmin (Enzyme that breaks down fibrin)
Goal: reestablish blood flow as quickly as possible, prevent/limit tissue damage
Main adverse effect: bleeding
Protamine sulfate is the antidote.
Contraindications: Hemorrhage, active internal bleeding