Huntington + Tourette Flashcards
what is the etiology of huntington disease?
autosomal dominant inheritance
what is the age of onset of huntington disease?
30-50 years old
what is the pathogenesis of huntington disease?
degeneration of GABA neurons, which are the inhibitors of movement
what is observed in autopsy of a patient with huntington disease? (2)
severe striatal atrophy + ventricle enlargement
what are the 2 main S&S of huntington disease?
dementia
chorea
what does progression of dementia look like in huntington disease? (4)
irritability to…
moodiness to …
psychiatric disturbance to …
dementia
what is the progression of chorea in huntington disease? (3)
restlessness to …
fidgetiness to …
chorea/dystonia
what are 3 imaging to obtain to diagnose huntington disease?
CT/MRI
PET scan
what will be seen in a CT/MRI of a patient with huntington disease? (2)
atrophy
cerebral atrophy
atrophy of caudate nucleus
what will be seen in a PET scan of a patient with huntington disease?
reduced striatal metabolic rate
how is a diagnosis of huntington disease made?
genetic testing
what is the treatment goal for huntington disease?
symptomatic
what medication can be used for huntington to reduce movement and improve dyskinesia?
tetrabenazine for chorea
what medication can be used for huntington disease to control dyskinesia and behavioral disturbances?
haloperidol (antipsychotic)
what medication can be used for huntington disease for psychosis, disruptive behavioral symptoms without chorea?
“quiet for psychosis”
quetiapine