Carbamazepine Flashcards
Indications for use
Antiepileptic, bipolar disorder
MOA
Blockage of sodium channel that leads to a decrease of neuronal impulse (excitability)
Pharmacological effects
Anticonvulsant
Pharmacokinetics (way of administration, metabolism, elimination, T1/2)
Oral, liver, urine (18-55 hours for initial/short-term use and 5-26 hours for long-term use )
Overdose effects
Respiratory depression, hypothermia, skin lesions
Side effects
Dizziness, drowsiness, vertigo, ataxia, hallucinations
Contraindications for use
sensitivity, atrioventricular block
Drug interactions
Carbamazepine increases the activity of microsomal liver enzymes and may reduce the effectiveness of drugs metabolized in the liver.
Interactions with products (meal), drinks
avoid the regular consumption ofgrapefruits and grapefruit juice
Children
More than 4 years (20-60 mg/day)
Elderly patients
Use with caution (200- 600 mg per day)
Pregnant women
Category B
Overdose treatment
There is no specific antidote. Gastric lavage, administration of activated charcoal (late evacuation of gastric contents can lead to delayed absorption for 2–3 days and reappearance of intoxication symptoms), symptomatic therapy. Forced diuresis, hemodialysis and peritoneal dialysis are ineffective (dialysis is indicated for a combination of severe poisoning and renal failure). Children may require exchange transfusions. It is recommended to carry out hemosorption on carbon sorbents.
