Heme Malignancies Flashcards
Lymph nodes that are soft, tender, mobile but enlarged suggest…
inflammation/infection
Lymph nodes that are firm, rubbery, mobile and enlarged suggest…
lymphoma
Lymph nodes that are hard, fixed, non-tender suggest…
carcinoma
At what stage of hematopoiesis does lymphoma affect/occur
mature lymphocytes (B cells and mature T cells)
Describe leukemia
cancer of blood & bone marrow characterized by uncontrolled accumulation of malignant WBC
Describe the etiology of acute versus chronic leukemia
also myeloid vs lymphoid
Describe the difference in clinical presentation between acute and chronic leukemia
Describe the diagnosis of leukemia
Describe the risk factors for the different forms of leukemia (acute v chronic & myeloid v lymphoid)
Describe the etiology of acute myeloid leukemia and the common emergencies within
Describe the presentation of acute myeloid leukemia
Describe the presentation of tissue infiltration in AML
Describe the presentation of leukostasis in AML
Describe the presentation of disseminated intravascular coagulation in AML
Describe the presentation of tumor lysis syndrome in AML
Describe the treatment of AML
Describe the treatment for leukostasis in AML
leukapheresis & emergent initiation of chemo
Describe the treatment for DIC in AML
replace clotting factors and platelets & start chemo
Describe the treatment of tumor lysis syndrome in AML
hydrate, allopurinol to clear uric acid, dialysis as needed
Describe the etiology of acute lymphoblastic leukemia