GU dz (lec 19, 20) Flashcards
Treponema pallidum (syphilis) microbe characteristics?
G- spirochete
Obligate parasite
Ulcerative (inflamm response)
T. pallidum virulence factors?
Fibronectin coat -> antiphago
Hyaluronidase -> infiltration
T. syphilis epidemiology?
Human
Horizontal/Vertical transmission
Direct contact
T. syphilis 1º?
Subepith entry
Local multiplication -> lymph nodes/blood
Chancre (raised/firm border)-> heals 3-8 wks
T. syphilis 2º?
Dormancy 2-10 wks
↑↑ contagious rash (doesn’t spare palms/plantar)
Immune complexes in arteries
T. syphilis latent?
No sxs
Early - can relapse
> 1 yr - immune to relapse
T. syphilis 3º?
5-20 yrs post
Meningovascular/neuro Δs or
CV w/ aortic aneurysm or
Granulomata in skin/bones
Congenital syphilis presentation?
Signs @ 3 wks: Rash, Nasal obstruction w/ infectious d/c, Osteitis of nasal bone, Neurosyph
Hutchinson’s Triad is?
w/ congen syph:
Notched incisors,
Interstitial keratitis,
8th nn deafness
Syphilis tests?
Darkfield/immunofluo -> 1º or 2º
Serum antibodies:
Screen w/ VDRL, RPR
Confirm w/ treponemal Ab tests
N. gonorrhoeae microbe characteristics?
G- kidney bean diplo
N. gonorrhoeae virulence factors?
Antigenic variation of pili Plasmid/Chromo resistance to abx Nonpili phase -> Φ antibodies Porin proteins -> attachment IgA protease
N. gonorrhoeae resistant to what abx?
PCN
TCN
Fluoroq
N. gonorrhoeae epidemiology?
(U) adolescents
(U) asymp carrier
N. gonorrhoeae infection mechanism?
Epith attachment (pili, memb prot)
Δ surface proteins (anti-ant, antiphago)
LOS/pepgly cell injury
Pilar spread
N. gonorrhoeae presentation:
W?
M?
Colonization of endocirvix/urethra
Colonization of ant urethra w/ white d/c
N. gonorrhoeae complications?
Acute salpingitis (fallop tube)
PID
Disseminated Gonococcal Infection (DGI)
DGI presentation?
fever/rash
purulent arthritis
N. gonorrhoeae tests?
Nucleic Acid Amp (PCR) dx