24th January Flashcards
1
Q
What is the largest cause of death in the UK after heart disease?
A
Cancer
2
Q
How many people in the UK will suffer from cancer
A
> 1 in 3
3
Q
How many people survive cancer?
A
> 50%
4
Q
What are the four most prevalent forms of cancer?
A
Lung (22%), colorectal (10%), breast (16%) and prostate (13%)
5
Q
What are the two main reasons that cancer deaths fell by 17% between 1978 and 2007?
A
Increased early diagnosis
Increased treatment
6
Q
Is cancer an age-related disease?
A
Yes
7
Q
What are the three main causes of cancer?
A
Lifestyle
Infectious Agents
Genetics
8
Q
What are the key lifestyle factors which cause cancer?
A
Occupational exposure Smoking Obesity Sunlight Lack of exercise
9
Q
What are the four main categories of treatment?
A
Surgery
Radiotherapy
Chemotherapy
Targeted therapy
10
Q
Outline the process of drug development
A
Target protein identification Target validation Design HT assay to identify inhibitors of target Identify lead inhibitors Optimise lead inhibitors Synthesis/formulation Toxicology studies in animals Clinical trials Market
